Yamaguchi Takashi, Lin Dayu
Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.
Neuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Curr Opin Behav Sci. 2018 Dec;24:104-112. doi: 10.1016/j.cobeha.2018.06.011. Epub 2018 Jul 3.
Aggression is a crucial survival behavior: it is employed to defend territory, compete for food and mating opportunities, protect kin, and resolve disputes. Although widely differing in its behavioral expression, aggression is observed across many species. The neural substrates of aggression have been investigated for nearly a century and two highly conserved circuitries emerge as critical substrates for generating and modulating aggression. One circuitry centers on the medial hypothalamus. Activity of the medial hypothalamic cells closely correlates with attacks and can bi-directionally modulate aggressive behaviors. The other aggression-related circuit involves the mesolimbic dopamine cells. Dopaminergic antagonists are the most commonly used treatment for suppressing human aggression in psychotic patients. Animal studies support essential roles of dopaminergic signaling in the nucleus accumbens in assessing the reward value of aggression and reinforcing the aggressive behaviors. In this review, we will provide an overview regarding the functions of medial hypothalamus and dopaminergic system in mediating aggressive behaviors and the potential interactions between these two circuitries.
它被用于保卫领地、争夺食物和交配机会、保护亲属以及解决争端。尽管攻击行为在行为表现上差异很大，但在许多物种中都能观察到。对攻击行为的神经基础的研究已经进行了近一个世纪，并且出现了两个高度保守的神经回路，它们是产生和调节攻击行为的关键基础。一个神经回路以内侧下丘脑为中心。内侧下丘脑细胞的活动与攻击行为密切相关，并且可以双向调节攻击行为。另一个与攻击行为相关的神经回路涉及中脑边缘多巴胺能细胞。多巴胺能拮抗剂是治疗精神病患者攻击行为最常用的药物。动物研究支持伏隔核中多巴胺能信号在评估攻击行为的奖励价值和强化攻击行为方面的重要作用。在这篇综述中，我们将概述内侧下丘脑和多巴胺能系统在介导攻击行为中的功能以及这两个神经回路之间的潜在相互作用。
