de Oliveira Jefferson Alvim, Freitas Michelle A R, de Oliveira Enio Chaves, Jabari Samir, Brehmer Axel, da Silveira Alexandre Barcelos Morais
Human Anatomy Sector, Neurosciences Laboratory, ICBIM, Campus Umuarama, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil.
Parasitology Sector, ICBIM, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil.
Parasitol Res. 2019 Apr;118(4):1325-1329. doi: 10.1007/s00436-019-06241-w. Epub 2019 Feb 12.
Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America. One of its clinical forms is Chagas megacolon. Despite being known for more than half a century, detailed causes are still obscure. Recent evidence indicates a close relationship between the immune system and the enteric nervous system in the etiology of chagasic megacolon pathology. It is believed that low expression of the 5-HT serotonin receptor on lymphocytes could be linked to megacolon development. To test this hypothesis, this work investigated the distribution of CD4, CD8, and CD20 lymphocytes and their 5-HT receptor expression. The results demonstrated that Chagas patients without megacolon present a higher expression of the 5-HT receptor in all analyzed lymphocytes compared with Chagas patients with megacolon. These data suggest that the high expression of this receptor may lead to immunomodulation and prevent the development of Chagas megacolon.
恰加斯病由克氏锥虫引起，仍是拉丁美洲最被忽视的疾病之一。其临床形式之一是恰加斯巨结肠。尽管已被知晓半个多世纪，但具体病因仍不清楚。最近的证据表明，在恰加斯病巨结肠病理的病因学中，免疫系统与肠神经系统之间存在密切关系。据信淋巴细胞上5-羟色胺（5-HT）血清素受体的低表达可能与巨结肠的发展有关。为了验证这一假设，本研究调查了CD4、CD8和CD20淋巴细胞的分布及其5-HT受体表达。结果表明，与患有巨结肠的恰加斯病患者相比，未患巨结肠的恰加斯病患者在所有分析的淋巴细胞中5-HT受体表达更高。这些数据表明，该受体的高表达可能导致免疫调节并预防恰加斯巨结肠的发展。
