高亲和力荧光配体用于 5-HT(3)受体。
High-affinity fluorescent ligands for the 5-HT(3) receptor.
机构信息
Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
出版信息
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1151-5. doi: 10.1016/j.bmcl.2011.11.097. Epub 2011 Dec 1.
Abstract
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.
摘要
描述了一小批荧光 5-HT(3) 受体配体的合成、光物理和生物学特性。这些新型格拉司琼缀合物中的几种具有高量子产率，并对人 5-HT(3)AR 表现出高亲和力。
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