Sacco N A, Filkins J P
Department of Anatomy, Loyola University of Chicago, Stritch School of Medicine, Maywood, Ill.
Magnesium. 1988;7(5-6):281-9.
The importance of monocytes and macrophages in antimicrobial host defense physiology has long been recognized. The mononuclear phagocyte system includes the precursor cells in bone marrow, or promonocytes, circulating peripheral blood monocytes, and the resident tissue macrophages of both fixed and free types. This review focuses on the pathophysiological role of the monokines, especially interleukin-1 in metabolic regulation during sepsis.
单核细胞和巨噬细胞在抗微生物宿主防御生理学中的重要性早已得到认可。单核吞噬细胞系统包括骨髓中的前体细胞，即前单核细胞、循环外周血单核细胞以及固定型和游离型的常驻组织巨噬细胞。本综述重点关注单核因子的病理生理作用，尤其是白细胞介素-1在脓毒症代谢调节中的作用。
