[The effect of ofloxacin therapy in acute salmonellosis on the duration of fecal excretion of Salmonella].

During an outbreak of food poisoning caused by Salmonella typhimurium, the duration of excretion of salmonella was studied for patients who received no antibiotic therapy and for those treated with Ofloxacin. In untreated group 85.7% of patients at 8 days and 28.5% of patients at 18 days were excreting S. typhimurium. However, in Ofloxacin-treated group only 25.0% of patients at 8 days and 5.0% of patients at 18 days were excreting S. typhimurium. The differences were statistically significant. We showed that Ofloxacin shortens the duration of excretion of S. typhimurium in feces. This phenomen may important in halting the spread of infection.