Department of Pharmacology, JSS College of Pharmacy, Ooty 643001, India.
Centre for Cancer Biology, University of South Australia and SA Patholology, Adelaide 5001, Australia.
Int J Mol Sci. 2019 Feb 11;20(3):749. doi: 10.3390/ijms20030749.
It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hypoxic. Cancer cells experiencing hypoxia undergo metabolic alterations and cytoprotective adaptive mechanisms to survive such stringent conditions. While such mechanisms provide potential therapeutic targets, the mechanisms by which hypoxia regulates adaptive responses-such as ER stress response, unfolded protein response (UPR), anti-oxidative responses, and autophagy-remain elusive. In this review, we summarize the complex interplay between hypoxia and the ER stress signaling pathways that are activated in the hypoxic microenvironment of the tumors.
显然，肿瘤内的区域会缺氧，使微环境缺氧。经历缺氧的癌细胞会经历代谢改变和细胞保护适应性机制以在这种严格的条件下存活。虽然这些机制提供了潜在的治疗靶点，但缺氧调节适应性反应的机制——如内质网应激反应、未折叠蛋白反应 (UPR)、抗氧化反应和自噬——仍然难以捉摸。在这篇综述中，我们总结了缺氧与内质网应激信号通路之间的复杂相互作用，这些信号通路在内质网应激信号通路在肿瘤的缺氧微环境中被激活。
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