中国阿片肽多态性与高血压的关联：一项荟萃分析。

The association between apelin polymorphisms and hypertension in China: A meta-analysis.

作者信息

Wang Tianyi, Liu Conghe, Jia Lili, Ding Jun

机构信息

1 NHC Key Laboratory of Radiobiology (Ministry of Health), Jilin University, P.R. China.

2 China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.

出版信息

J Renin Angiotensin Aldosterone Syst. 2019 Jan-Mar;20(1):1470320319827204. doi: 10.1177/1470320319827204.

DOI:10.1177/1470320319827204

PMID:30755060

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6376513/

Abstract

INTRODUCTION

: Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.

MATERIALS AND METHODS

: Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model.

RESULTS

: The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82-1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89-1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46-1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86-1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86-1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81-1.79).

CONCLUSION

: This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension.

摘要

引言

阿片肽在调节血压、新陈代谢以及癌症发展过程中发挥着重要作用。近期研究对阿片肽基因多态性与高血压风险之间的关联进行了调查，但尚未开展荟萃分析。

材料与方法

本荟萃分析共纳入五项研究。采用随机效应模型计算合并比值比及其相应的95%置信区间。

结果

rs3761581 G等位基因频率分布的总体合并比值比为0.90（95%置信区间：0.82 - 1.00）。在女性参与者中，G等位基因频率的合并比值比为1.01（95%置信区间：0.89 - 1.14）。对于男性，G等位基因频率的合并比值比为0.69（95%置信区间：0.46 - 1.03）。至于rs56204867，G等位基因频率的总体合并比值比为1.09（95%置信区间：0.86 - 1.37）。在女性中，G等位基因频率的合并比值比为1.05（95%置信区间：0.86 - 1.29）。在男性参与者中，G等位基因频率与高血压未显示出显著相关性（合并比值比 = 1.21，95%置信区间：0.81 - 1.79）。