中国人血管紧张素原基因多态性与原发性高血压的相关性研究。

Association of polymorphisms in the AGT gene with essential hypertension in the Chinese population.

机构信息

Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China.

出版信息

J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):282-8. doi: 10.1177/1470320311430991. Epub 2011 Dec 12.

DOI:10.1177/1470320311430991

PMID:22156763

Abstract

OBJECTIVE

Although the angiotensinogen (AGT) gene has been implicated in the pathogenesis of essential hypertension, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of A-6G, A-20C and G-217A polymorphisms in the AGT gene with essential hypertension in the Chinese population.

METHODS

Published literature from PubMed, Embase, China National Knowledge Infrastructure, China Biological Medicine and Wanfang Data was retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models.

RESULTS

Sixteen studies (4223 cases and 3743 controls) for A-6G polymorphism, ten studies (3116 cases and 2678 controls) for A-20C polymorphism and five studies (1268 cases and 1081 controls) for G-217A polymorphism were identified. The results from the meta-analyses indicated significant association of all three polymorphism with the risk of essential hypertension in the Chinese population (A-6G polymorphism: GG vs AA: OR = 1.45, 95% CI 1.17-1.81; A-20C polymorphism: CC vs AA: OR = 1.52, 95% CI 1.10-2.08; G-217A polymorphism: AA vs GG: OR = 2.36, 95% CI 1.44-3.89).

CONCLUSIONS

Our study indicated that three polymorphisms (A-6G, A-20C and G-217A) in the AGT gene are associated with essential hypertension in the Chinese population.

摘要

目的

尽管血管紧张素原（AGT）基因与原发性高血压的发病机制有关，但结果并不一致。本研究通过荟萃分析评估了 AGT 基因中的 A-6G、A-20C 和 G-217A 多态性与中国人原发性高血压的相关性。

方法

检索了 PubMed、Embase、中国知网、中国生物医学文献数据库和万方数据中已发表的文献。使用固定或随机效应模型计算合并优势比（OR）及其 95%置信区间（CI）。

结果

共纳入了 16 项研究（4223 例病例和 3743 例对照）用于 A-6G 多态性，10 项研究（3116 例病例和 2678 例对照）用于 A-20C 多态性，5 项研究（1268 例病例和 1081 例对照）用于 G-217A 多态性。荟萃分析结果表明，这三种多态性均与中国人原发性高血压的发病风险相关（A-6G 多态性：GG 与 AA：OR=1.45，95%CI 1.17-1.81；A-20C 多态性：CC 与 AA：OR=1.52，95%CI 1.10-2.08；G-217A 多态性：AA 与 GG：OR=2.36，95%CI 1.44-3.89）。