Azorin J M, Karege F, Valli M, Pringuey D, Joanny P, Tissot R
Department of Psychiatry, Timone Hospital, Aix-Marseille University, France.
Neuropsychobiology. 1988;20(2):67-73. doi: 10.1159/000118475.
Animal studies have suggested interspecies differences in brain norepinephrine (NE) metabolism, especially with regard to the relative proportions of 3,4-dihydroxyphenylethyleneglycol (DOPEG) compared to 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG). In order to question the value of both glycol metabolites as peripheral indices of central noradrenergic activity, a comparative study of plasma DOPEG and MOPEG (measured by HPLC) related to depression, sex, age and diagnostic categories (DSM-III) was carried out on depressed and control subjects. In addition, two groups of 8 patients were randomly submitted to a desipramine 150 mg/day, or a metapramine 450 mg/day antidepressant treatment influencing the formation of DOPEG and MOPEG in a different way. The study did not demonstrate any difference between DOPEG and MOPEG for most of the experimental factors. We found also a significant positive correlation between plasma levels of DOPEG and MOPEG. Our results support the idea that each of these two biological indices can be used in the assessment of central noradrenergic activity.
动物研究表明，大脑去甲肾上腺素（NE）代谢存在种间差异，尤其是在3,4-二羟基苯乙二醇（DOPEG）与3-甲氧基-4-羟基苯乙二醇（MOPEG）的相对比例方面。为了质疑这两种二醇代谢产物作为中枢去甲肾上腺素能活性外周指标的价值，我们对抑郁症患者和对照受试者进行了一项比较研究，分析血浆DOPEG和MOPEG（通过高效液相色谱法测定）与抑郁症、性别、年龄和诊断类别（DSM-III）之间的关系。此外，两组各8名患者被随机给予每日150毫克地昔帕明或每日450毫克间普拉明的抗抑郁治疗，这两种治疗以不同方式影响DOPEG和MOPEG的形成。对于大多数实验因素，该研究未显示DOPEG和MOPEG之间存在任何差异。我们还发现血浆DOPEG水平与MOPEG水平之间存在显著正相关。我们的结果支持这样一种观点，即这两种生物学指标均可用于评估中枢去甲肾上腺素能活性。
