抑郁症患者血浆DOPEG水平与尿液MOPEG水平之间缺乏相关性。
Lack of correlation between plasma DOPEG and urinary MOPEG levels in depressed patients.
作者信息
Lôo H, Dennis T, Vanelle J M, Rouquier L, Poirier-Littré M F, Garreau M, Benkelfat C, Sechter D, Scatton B
出版信息
Biol Psychiatry. 1986 Aug;21(10):900-6. doi: 10.1016/0006-3223(86)90263-5.
Twenty-four-hour urinary excretion of 3-methoxy,4-hydroxyphenylethyleneglycol (MOPEG) and levels of free and conjugated plasma 3,4-dihydroxyphenylethyleneglycol (DOPEG) were measured in 56 depressed patients to find a possible correlation between these two peripheral indices of cerebral noradrenergic activity. Plasma DOPEG was measured at 9:00 AM on the same day that urine was collected for the measurement of MOPEG. All depressed patients were diagnosed as having affective disorders according to DSM-III. No correlation was found between plasma free or conjugated DOPEG levels and urinary MOPEG output. This lack of correlation was found in the total sample of depressed patients (56), in 45 patients diagnosed as having major depressive episodes, and in 24 depressed patients diagnosed as major depressive with melancholia. The authors discuss the significance of this lack of correlation between two peripheral indices of central noradrenergic metabolism.
对56名抑郁症患者测量了3-甲氧基-4-羟基苯乙二醇（MOPEG）的24小时尿排泄量以及游离和结合态血浆3,4-二羟基苯乙二醇（DOPEG）的水平，以探寻这两个脑去甲肾上腺素能活性外周指标之间可能存在的相关性。在收集尿液以测量MOPEG的同一天上午9点测量血浆DOPEG。所有抑郁症患者均根据《精神疾病诊断与统计手册》第三版（DSM-III）被诊断为患有情感障碍。未发现血浆游离或结合态DOPEG水平与尿MOPEG排出量之间存在相关性。在抑郁症患者总样本（56例）、45例被诊断为重度抑郁发作的患者以及24例被诊断为重度抑郁伴 melancholia的抑郁症患者中均发现了这种缺乏相关性的情况。作者讨论了中枢去甲肾上腺素能代谢的两个外周指标之间缺乏相关性的意义。
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