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垂盆草通过调节 FGF-7 和 FGF-5 促进毛发生长，维持毛发生长期。

Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5.

机构信息

a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.

b Jeonju AgroBio-Materials Institute , Jeonju-si , Republic of Korea.

出版信息

Pharm Biol. 2019 Dec;57(1):105-111. doi: 10.1080/13880209.2018.1561729.

DOI:10.1080/13880209.2018.1561729
PMID:30757935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6374973/
Abstract

CONTEXT

Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine.

OBJECTIVE

This study investigates the potency of EP in promoting hair growth in vivo and in vitro.

MATERIALS AND METHODS

C57BL/6N mice were divided into four groups (n = 4) as follows: control (topical treatment of normal saline), topical 3% minoxidil to the dorsal skin of mice for 14 days, and low (1 mg/day) and high (10 mg/day) doses of EP orally administered once a day for 14 days. Dorsal hairs of C57BL/6N mice were depilated to synchronize anagen induction. Hair growth activity was evaluated by gross and microscopic observations. Sections of dorsal skin were stained with haematoxylin and eosin. We also treated the various concentrations of EP (5, 10 and 50 μg/mL) for 24 h on the human dermal papilla cells (HDPs) and examined the effects of EP on the expression of FGF-7 and mTOR signalling.

RESULTS

EP enhanced the induction of anagen in the dorsal skin of mice, characterized by the appearance of inner root sheath along with hair shaft, the emergence of hair shaft through the epidermis. EP increased the expression of FGF-7, while decreased the level of FGF-5 in C57/BL6 mice. EP also increased the expression of FGF-7, activated the mTOR signalling in HDPs.

DISCUSSION AND CONCLUSIONS

These results suggest that EP has a potency to enhance the growth of hair follicle, promoting hair growth through regulation of FGF-7 and FGF-5.

摘要

背景

垂盆草（EP）（菊科）在亚洲传统医学中被广泛用于治疗皮肤病。

目的

本研究调查 EP 在体内和体外促进毛发生长的效力。

材料和方法

C57BL/6N 小鼠分为四组（n=4）：对照组（背部皮肤涂生理盐水）、局部使用 3%米诺地尔 14 天、低（1mg/天）和高（10mg/天）剂量 EP 口服，每天一次，共 14 天。C57BL/6N 小鼠背部毛发剃毛以同步诱导生长期。通过肉眼和显微镜观察评估毛发生长活性。用苏木精和伊红染色背部皮肤切片。我们还在人真皮乳头细胞（HDPs）上处理不同浓度的 EP（5、10 和 50μg/mL）24 小时，并检查 EP 对 FGF-7 和 mTOR 信号的表达的影响。

结果

EP 增强了小鼠背部皮肤的生长期诱导，表现为内根鞘与毛干一起出现，毛干通过表皮出现。EP 增加了 FGF-7 的表达，同时降低了 C57/BL6 小鼠中 FGF-5 的水平。EP 还增加了 FGF-7 的表达，激活了 HDPs 中的 mTOR 信号。

讨论与结论

这些结果表明，EP 具有增强毛囊生长的效力，通过调节 FGF-7 和 FGF-5 促进毛发生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/95418c33fc78/IPHB_A_1561729_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/ef4243de5155/IPHB_A_1561729_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/b7009403b0dc/IPHB_A_1561729_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/d2add6d458a6/IPHB_A_1561729_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/dc32f6dfa845/IPHB_A_1561729_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/95418c33fc78/IPHB_A_1561729_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/ef4243de5155/IPHB_A_1561729_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/b7009403b0dc/IPHB_A_1561729_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/d2add6d458a6/IPHB_A_1561729_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/dc32f6dfa845/IPHB_A_1561729_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b20/6374973/95418c33fc78/IPHB_A_1561729_F0005_C.jpg

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