Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Thorac Cancer. 2019 Apr;10(4):791-798. doi: 10.1111/1759-7714.13000. Epub 2019 Feb 13.
Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm.
From January 2000 to January 2018, 20 patients with a diagnosis of thymic neoplasm and bronchiectasis were hospitalized at the Peking Union Medical College Hospital. Clinical data was retrospectively analyzed.
The prevalence of bronchiectasis in thymic neoplasms in our cohort was 1.56% (20/1279). Eighteen patients were diagnosed with thymoma, while two patients were diagnosed with thymic carcinoid. The duration from diagnosis of thymic neoplasm to bronchiectasis varied. Distributions of bronchiectasis were bilateral in 17 patients and unilateral in three patients. Four patients were previously diagnosed with diffuse panbronchiolitis and another two were suspected with diffuse panbronchiolitis. Twelve patients had various parathymic syndromes, including Good syndrome, myasthenia gravis, and aplastic anemia. Thymectomy was performed in all of these patients. Macrolide antibiotics were administered to 10 patients, and the symptoms improved in 8.
Bronchiectasis is a complication in thymic neoplasms, although prevalence is low. There may be multifactorial etiologies for bronchiectasis in patients with thymic neoplasms. Comprehensive treatment should be carried out to ensure optimal outcomes.
支气管扩张症是胸腺瘤患者罕见的并发症。本研究旨在探讨胸腺瘤合并支气管扩张症患者的临床和影像学表现、实验室检查、病理特征和治疗转归。
回顾性分析 2000 年 1 月至 2018 年 1 月期间在北京协和医院住院的 20 例胸腺瘤合并支气管扩张症患者的临床资料。
本队列中胸腺瘤合并支气管扩张症的患病率为 1.56%（20/1279）。18 例患者诊断为胸腺瘤，2 例患者诊断为胸腺癌。从胸腺瘤诊断到支气管扩张症的时间长短不一。17 例患者为双侧支气管扩张，3 例为单侧支气管扩张。4 例患者既往被诊断为弥漫性泛细支气管炎，另外 2 例患者疑似弥漫性泛细支气管炎。12 例患者存在各种胸外副瘤综合征，包括 Good 综合征、重症肌无力和再生障碍性贫血。所有患者均接受了胸腺切除术。10 例患者接受了大环内酯类抗生素治疗，其中 8 例症状改善。
支气管扩张症是胸腺瘤的一种并发症，尽管患病率较低，但发病机制可能是多因素的。应采取综合治疗措施，以确保获得最佳疗效。
