Stanhope R, Preece M A, Grant D B, Brook C G
Department of Growth and Development, Institute of Child Health, London, UK.
Acta Paediatr Scand Suppl. 1988;347:30-7.
The timing of the growth spurt of normal children does not affect their final height attainment. Growth rate during the growth acceleration of puberty correlates with changes in GH, and not sex steroid, secretion. GH secretion during puberty is pulse amplitude, and not frequency, modulated. In both central precocious puberty and normal puberty suppressed with a GnRH analogue, the rate of epiphyseal maturation is decreased as are GH pulse amplitude and growth, but with no influence on final height.
正常儿童生长突增的时间并不影响其最终身高。青春期生长加速期间的生长速率与生长激素（GH）的变化相关，而非与性类固醇分泌相关。青春期期间GH的分泌是由脉冲幅度而非频率调节的。在中枢性性早熟和用促性腺激素释放激素（GnRH）类似物抑制的正常青春期中，骨骺成熟速率均降低，GH脉冲幅度和生长也降低，但对最终身高无影响。
