Veldhuis J D, Faria A, Vance M L, Evans W S, Thorner M O, Johnson M L
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.
Acta Paediatr Scand Suppl. 1988;347:63-82.
The evaluation of episodic GH release is made difficult by the apparently random nature of GH secretory bursts, the frequent occurrence of minimally detectable plasma GH concentrations, the relatively rapid plasma disappearance rate of endogenous GH, and the large number of metabolic and environmental cues that alter GH dynamics. Nonetheless, the development of objective, statistically based, and reproducible computerized algorithms to quantify episodic GH release has offered new insights into the pathophysiological regulation of GH secretion in health and disease. Moreover, the recent formulation of algebraically explicit biophysical models of GH secretion and clearance has made possible a complete quantitative description of GH secretory and clearance dynamics over a full 24 hours of observation. Such analytical tools allow investigators to enumerate with statistically bounded confidence limits the number, amplitude, durations, and temporal locations of all significant underlying secretory bursts and simultaneously calculate the half-life of endogenous GH disappearance from all GH concentrations and their variances considered together. Accordingly, in conjunction with contemporary refinements in GH assay techniques, such novel approaches to dissecting the temporal structure of GH secretion and clearance in vivo should result in significantly enhanced understanding of GH dynamics in health and disease.
生长激素（GH）分泌突发具有明显的随机性，血浆GH浓度常常难以检测到，内源性GH在血浆中的消失速率相对较快，以及大量改变GH动态的代谢和环境线索，这些都使得评估间歇性GH释放变得困难。尽管如此，基于统计学且可重复的客观计算机算法的发展，用于量化间歇性GH释放，为健康和疾病状态下GH分泌的病理生理调节提供了新的见解。此外，最近对GH分泌和清除的代数显式生物物理模型的构建，使得在完整的24小时观察期内对GH分泌和清除动态进行完整的定量描述成为可能。此类分析工具使研究人员能够以具有统计学界定的置信限，列举出所有显著的潜在分泌突发的数量、幅度、持续时间和时间位置，并同时根据所有考虑在内的GH浓度及其方差计算内源性GH消失的半衰期。因此，结合当代GH检测技术的改进，这种剖析体内GH分泌和清除时间结构的新方法，应能显著增强对健康和疾病状态下GH动态的理解。
