Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research Stockholm, Box 4044, 141 04 Stockholm, Sweden.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
J Clin Psychiatry. 2019 Feb 12;80(2):18m12172. doi: 10.4088/JCP.18m12172.
The risk of suicide is elevated after discharge from a psychiatric hospital. This study aimed to investigate how recent suicidal behavior affects the risk of suicide in patients with different psychiatric diagnoses immediately after discharge.
Registers with national coverage were linked to create a study cohort including all individuals discharged from psychiatric hospitals in Sweden from 1973 through 2009. Hazard ratios for discharge diagnoses were calculated. The risk of suicide within 30 days after discharge in each diagnostic category when suicidal behavior had been registered within 30 days before admission was estimated.
A total of 3,695 suicides occurred after 2,883,088 discharges. If recent suicidal behavior was registered, the risk of completed suicide increased prominently in all diagnostic categories, but particularly for schizophrenia (hazard ratio [HR] = 8.9; 95% CI, 6.4-12.4) and other nonorganic psychosis (HR = 6.8; 95% CI, 5.1-9.0). Patients suffering from depression had the highest overall risk of suicide postdischarge (HR = 3.0; 95% CI, 2.7-3.3). This finding applied especially to male patients with depression (HR = 4.5; 95% CI, 4.0-5.0) or with reaction to crisis (HR = 3.6; 95% CI 3.0-4.4).
A distinct elevation of the risk of suicide was seen in all diagnostic groups if a recent self-harm event had occurred, particularly among patients with psychotic disorders. Overall, the immediate risk of suicide after discharge was high regardless of recent suicidal behavior. The findings in this study have relevance for clinical decisions about immediate after-care and treatment in connection with discharge from psychiatric inpatient care.
精神科医院出院后自杀风险升高。本研究旨在调查近期自杀行为如何影响不同精神科诊断患者出院后立即自杀的风险。
通过国家登记系统进行链接,创建了一个研究队列,其中包括 1973 年至 2009 年期间从瑞典精神病院出院的所有患者。计算了出院诊断的风险比。当在入院前 30 天内记录到自杀行为时,估计了每个诊断类别中在出院后 30 天内自杀的风险。
在 2883088 次出院后共发生了 3695 例自杀。如果最近有自杀行为记录,在所有诊断类别中,自杀风险显著增加,但精神分裂症(风险比 [HR] = 8.9;95%CI,6.4-12.4)和其他非器质性精神病(HR = 6.8;95%CI,5.1-9.0)的风险增加更为显著。患有抑郁症的患者出院后总体自杀风险最高(HR = 3.0;95%CI,2.7-3.3)。这一发现尤其适用于男性抑郁症患者(HR = 4.5;95%CI,4.0-5.0)或对危机有反应的患者(HR = 3.6;95%CI 3.0-4.4)。
如果最近发生了自我伤害事件,所有诊断组的自杀风险都会明显升高,尤其是精神病患者。总体而言,无论最近是否有自杀行为,出院后立即自杀的风险都很高。本研究的结果与精神科住院患者出院后立即进行后续护理和治疗的临床决策有关。