对有先兆子痫危险因素的孕妇进行D-二聚体和纤溶酶原激活物抑制剂-1血浆水平的纵向评估。
Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.
作者信息
Lucena Flávia Campos, Lage Eura Martins, Teixeira Patrícia Gonçalves, Barbosa Alexandre Simões, Diniz Rejane, Lwaleed Bashir, Talvani André, Alpoim Patrícia Nessralla, Perucci Luiza Oliveira, Dusse Luci Maria SantAna
机构信息
a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil.
b Department of Gynecology and Obstetrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brazil.
出版信息
Hypertens Pregnancy. 2019 Feb;38(1):58-63. doi: 10.1080/10641955.2019.1577435. Epub 2019 Feb 13.
OBJECTIVE
Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.
METHODS
D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.
RESULTS
D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups.
CONCLUSION
D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.
目的
研究有子痫前期（PE）风险因素的女性在整个孕期的D-二聚体/D-Di和纤溶酶原激活物抑制剂1型（PAI-1）水平。
方法
对28名女性在妊娠12 - 19周、20 - 29周、30 - 34周和35 - 40周时测定血浆D-Di和PAI-1水平。
结果
与未发生PE的女性相比，发生PE的女性在12 - 19周时D-Di较低，在30 - 34周时较高。两组中D-Di在整个孕期均升高，发生PE的孕妇比未发生PE的孕妇更早达到峰值。PAI-1在整个孕期升高，但两组间无差异。
结论
D-Di能够在妊娠12 - 19周和30 - 34周时区分这些女性群体。
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