OBJECTIVE: The current review briefly addresses the history of neuropsychology as a context for discussion of developmental milestones that have advanced the profession, as well as areas where the progression has lagged. More recently in the digital/information age, utilization and incorporation of emerging technologies has been minimal, which has stagnated ongoing evolution of the practice of neuropsychology despite technology changing many aspects of daily living. These authors advocate for embracing National Institutes of Health (NIH) initiatives, or interchangeably referred to as transformative opportunities, for the behavioral and social sciences. These initiatives address the need for neuropsychologists to transition from fragmented and data-poor approaches to integrated and data-rich scientific approaches that ultimately improve translational applications. Specific to neuropsychology is the need for the adoption of novel means of brain-behavior characterizations. METHOD: Narrative review Conclusions: Clinical neuropsychology has reached a developmental plateau where it is ready to embrace the measurement science and technological advances which have been readily adopted by the human neurosciences. While there are ways in which neuropsychology is making inroads into these areas, a great deal of growth is needed to maintain relevance as a scientific discipline (see Figures 1, 2, and 3) consistent with NIH initiatives to advance scientific developments. Moreover, implications of such progress require discussion and modification of training, ethical, and legal mandates of the practice of neuropsychology.