Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Department of Gynaecology and Obstetrics, Geneva University Hospital, 30, bvd de la Cluse, 1205, Geneve, Switzerland.
Curr Stem Cell Res Ther. 2019;14(6):454-459. doi: 10.2174/1574888X14666190213100528.
Asherman's Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman's syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman's Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.
Asherman 综合征或宫腔粘连是一种获得性子宫疾病，其中子宫腔内形成纤维性瘢痕，导致月经量减少、盆腔疼痛和不孕。直到最近，导致纤维化形成的分子机制还知之甚少，Asherman 综合征的治疗主要集中在宫腔镜粘连切除术、激素治疗和物理屏障上。许多研究已经开始探索 Asherman 综合征纤维化过程背后的分子机制以及干细胞在子宫内膜再生中的作用作为一种治疗方式。本综述总结了现有的基于干细胞的再生研究，并强调了研究中的当前空白。
