复杂遗传性疾病的分子遗传学
The molecular genetics of complex inherited diseases.
作者信息
Williamson R
机构信息
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, University of London, Norfolk, UK.
出版信息
Br J Cancer Suppl. 1988 Dec;9:14-6.
Abstract
The majority of inherited diseases are due to unknown biochemical defects, or are either polygenetic or multifactorial. Due to advances in molecular genetics, it is now possible to study these conditions, either by reverse genetics (using cloning techniques to move from linkage to gene, and then determining the protein involved) or by dissecting a complex disease into a set of monogenic paradigms.
摘要
大多数遗传性疾病是由未知的生化缺陷引起的，或者是多基因或多因素的。由于分子遗传学的进展，现在可以通过反向遗传学（使用克隆技术从连锁关系找到基因，然后确定相关蛋白质）或通过将复杂疾病分解为一组单基因范例来研究这些病症。
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