Seidal T, Walaas L, Kindblom L G, Angervall L
Department of Pathology, University of Göteborg, Sahlgren's Hospital, Sweden.
Diagn Cytopathol. 1988;4(4):292-9. doi: 10.1002/dc.2840040405.
A correlated cytologic and histologic study of seven cases of embryonal rhabdomyosarcoma is presented. The diagnosis of rhabdomyosarcoma was established by light and electron microscopy and immunohistochemistry of the operative specimens. The cytologic appearance of the smears corresponded well with the histopathologic findings. Cytologically, two main cell types were distinguished: a predominant primitive, small round cell with scant cytoplasm and a large cell with an abundant cytoplasm, sometimes tadpole- or ribbon-shaped. The tumor cells were often enclosed in a background of mucosubstances. The lack of cytologic features proving rhabdomyoblastic differentiation, such as cross-striation, necessitates the use of additional methods in the cytologic diagnosis of embryonal rhabdomyosarcoma. The value of the embedding technique for ultrastructural analysis and immunohistochemistry in the demonstration of desmin in aspirates is emphasized in the diagnosis of embryonal rhabdomyosarcoma.
本文呈现了7例胚胎性横纹肌肉瘤的细胞学与组织学相关性研究。横纹肌肉瘤的诊断通过手术标本的光镜、电镜及免疫组化检查得以确立。涂片的细胞学表现与组织病理学结果高度相符。在细胞学上，可区分出两种主要细胞类型：一种以原始的、胞质稀少的小圆形细胞为主，另一种是胞质丰富的大细胞，有时呈蝌蚪形或带状。肿瘤细胞常被包裹于黏液物质背景中。由于缺乏证明横纹肌母细胞分化的细胞学特征，如横纹，因此在胚胎性横纹肌肉瘤的细胞学诊断中需要采用其他方法。在胚胎性横纹肌肉瘤的诊断中，强调了包埋技术在超微结构分析及免疫组化中对于显示吸出物中结蛋白的价值。
