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本文引用的文献

1
Multiple myeloma in the very elderly patient: challenges and solutions.老年患者的多发性骨髓瘤:挑战与解决方案
Clin Interv Aging. 2016 Apr 15;11:423-35. doi: 10.2147/CIA.S89465. eCollection 2016.
2
Multiple Myeloma: Diagnosis and Treatment.多发性骨髓瘤:诊断与治疗
Mayo Clin Proc. 2016 Jan;91(1):101-19. doi: 10.1016/j.mayocp.2015.11.007.
3
Phase 1/2 study of carfilzomib plus melphalan and prednisone in patients aged over 65 years with newly diagnosed multiple myeloma.卡非佐米联合马法兰和泼尼松治疗新诊断的多发性骨髓瘤且年龄超过 65 岁的患者的 1/2 期研究。
Blood. 2015 May 14;125(20):3100-4. doi: 10.1182/blood-2015-02-626168. Epub 2015 Mar 17.
4
Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report.老年评估可预测老年骨髓瘤患者的生存率和毒性:国际骨髓瘤工作组报告
Blood. 2015 Mar 26;125(13):2068-74. doi: 10.1182/blood-2014-12-615187. Epub 2015 Jan 27.
5
Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma.来那度胺联合地塞米松治疗不适合移植的骨髓瘤患者。
N Engl J Med. 2014 Sep 4;371(10):906-17. doi: 10.1056/NEJMoa1402551.
6
Multiple myeloma in the older adult: better prospects, more challenges.老年多发性骨髓瘤:前景更佳,挑战更多。
J Clin Oncol. 2014 Aug 20;32(24):2531-40. doi: 10.1200/JCO.2014.55.1028.
7
Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study.卡非佐米、环磷酰胺和地塞米松治疗新诊断多发性骨髓瘤患者的多中心、2 期研究。
Blood. 2014 Jul 3;124(1):63-9. doi: 10.1182/blood-2014-03-563759. Epub 2014 May 22.
8
Multiple myeloma in the very old: an IASIA conference report.非常老的多发性骨髓瘤:IASIA 会议报告。
J Natl Cancer Inst. 2014 Apr 3;106(5):dju067. doi: 10.1093/jnci/dju067.
9
How should we treat newly diagnosed multiple myeloma patients?我们应该如何治疗新诊断的多发性骨髓瘤患者?
Hematology Am Soc Hematol Educ Program. 2013;2013:488-95. doi: 10.1182/asheducation-2013.1.488.
10
Trends in use of and survival after autologous hematopoietic cell transplantation in North America, 1995-2005: significant improvement in survival for lymphoma and myeloma during a period of increasing recipient age.1995-2005 年北美自体造血细胞移植的应用和生存趋势:在受体年龄不断增加的时期,淋巴瘤和骨髓瘤的生存状况显著改善。
Biol Blood Marrow Transplant. 2013 Jul;19(7):1116-23. doi: 10.1016/j.bbmt.2013.04.027. Epub 2013 May 6.

老年多发性骨髓瘤的治疗:文献综述与实践指南

Treatment of Multiple Myeloma in Elderly Patients: A Review of Literature and Practice Guidelines.

作者信息

Manapuram Suresh, Hashmi Hamza

机构信息

Internal Medicine, Saint Francis Hospital and Medical Center, Grand Island, USA.

Oncology, University of Louisville School of Medicine, Louisville, USA.

出版信息

Cureus. 2018 Dec 1;10(12):e3669. doi: 10.7759/cureus.3669.

DOI:10.7759/cureus.3669
PMID:30761222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6364954/
Abstract

Multiple myeloma (MM) is a clonal disorder of malignant plasma cells that comprises approximately 10% of hematologic malignancies. With median age of 66 at the time of presentation, multiple myeloma is predominantly a disease of the elderly. The availability of new combination regimens and the enhanced safety of autologous hematopoietic stem cell transplant has increased the treatment options for elderly patients with multiple myeloma. We provide a summary of data supporting the current management of elderly patients with newly diagnosed multiple myeloma.

摘要

多发性骨髓瘤(MM)是一种恶性浆细胞的克隆性疾病,约占血液系统恶性肿瘤的10%。多发性骨髓瘤患者确诊时的中位年龄为66岁,主要是一种老年疾病。新的联合治疗方案的出现以及自体造血干细胞移植安全性的提高,增加了老年多发性骨髓瘤患者的治疗选择。我们总结了支持当前新诊断的老年多发性骨髓瘤患者管理的数据。