土耳其麻疹免疫评估：麻疹仍构成威胁吗？

Evaluation of measles immunity in Turkey: is it still a threat?

出版信息

Turk J Med Sci. 2019 Feb 11;49(1):336-340. doi: 10.3906/sag-1809-54.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7350803/

Abstract

BACKGROUND/AIM: Measles is one of the important vaccine-preventable diseases with many complications in childhood. This study presents cross-sectional seroepidemiological data, beginning from neonatal cord blood in infants to children under 6 years of age, about waning of measles antibody and tries to suggest the proper time for measles immunization.

MATERIALS AND METHODS

A total of 564 blood samples consisting of neonatal cord blood and samples taken from infants and children at ages of 6, 9, 24–48, and 49–72 months were analyzed for measles seropositivity in a period of 6 months.

RESULTS

Measles seropositivity rate was 72.5% in 109 cord blood samples, 2.6% in 117 infants of 6 months of age, and 3.6% in 111 infants of 9 months of age. Seropositivity was determined in 118 children at 24–48 months and in 109 children at 49–72 months and was 80.5% and 66%, respectively (P = 0.001). These children were vaccinated in the 12th month.

CONCLUSION

Though measles immunization coverage is 97% in Turkey, population immunity is somewhat lower than expected. Increases of measles cases in Europe and the refugee problem in the country could easily lead to outbreaks. Implementing the first dose of the immunization at 9 months may be an option.

摘要

背景/目的：麻疹是一种重要的疫苗可预防疾病，在儿童期有许多并发症。本研究提供了从新生儿脐带血到 6 岁以下儿童的横断面血清流行病学数据，了解麻疹抗体的衰减情况，并试图提出适当的麻疹免疫时间。

材料和方法

在 6 个月的时间内，对 564 份血液样本进行了分析，这些样本包括新生儿脐带血和 6 个月、9 个月、24-48 个月和 49-72 个月龄婴儿的样本，以检测麻疹血清阳性率。

结果

109 份脐带血样本中麻疹血清阳性率为 72.5%，117 名 6 个月大婴儿为 2.6%，111 名 9 个月大婴儿为 3.6%。在 24-48 个月的 118 名儿童和在 49-72 个月的 109 名儿童中确定了血清阳性率，分别为 80.5%和 66%（P=0.001）。这些儿童在 12 个月大时接种了疫苗。