• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Preliminary evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines.

作者信息

Kondeva-Burdina Magdalena, Georgieva Maya, Kasabova-Angelova Alexandra, Tzankova Virginia, Zlatkov Alexander

机构信息

Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria.

出版信息

Neural Regen Res. 2019 Jun;14(6):971-972. doi: 10.4103/1673-5374.250573.

DOI:10.4103/1673-5374.250573
PMID:30762003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404505/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4200/6404505/c05b09b5b42d/NRR-14-971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4200/6404505/f4ebaa0bc385/NRR-14-971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4200/6404505/c05b09b5b42d/NRR-14-971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4200/6404505/f4ebaa0bc385/NRR-14-971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4200/6404505/c05b09b5b42d/NRR-14-971-g002.jpg

相似文献

1
Preliminary evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines.
Neural Regen Res. 2019 Jun;14(6):971-972. doi: 10.4103/1673-5374.250573.
2
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.用于神经退行性疾病的新型多功能神经保护铁螯合剂 - 单胺氧化酶抑制剂药物：抗氧化活性、预防脂质过氧化物形成及单胺氧化酶抑制的体外研究
J Neurochem. 2005 Oct;95(1):68-78. doi: 10.1111/j.1471-4159.2005.03340.x.
3
Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.一种新型铁螯合剂-脑选择性单胺氧化酶-A/单胺氧化酶-B抑制剂在帕金森病和衰老动物模型中的神经保护和神经修复活性。
Neurobiol Aging. 2015 Mar;36(3):1529-42. doi: 10.1016/j.neurobiolaging.2014.10.026. Epub 2014 Oct 22.
4
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.新型芳基烯基炔丙胺作为神经保护、强效且选择性的单胺氧化酶B抑制剂用于治疗帕金森病。
J Med Chem. 2015 Feb 12;58(3):1400-19. doi: 10.1021/jm501722s. Epub 2015 Jan 28.
5
Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke.从烟草烟雾中分离和鉴定一种单胺氧化酶B选择性抑制剂。
Bioorg Med Chem. 2006 May 15;14(10):3392-8. doi: 10.1016/j.bmc.2005.12.057. Epub 2006 Feb 3.
6
Early change in mitochondrial monoamine oxidase activity of rat liver during 2-acetylaminofluorene feeding.
Biochim Biophys Acta. 1981 Oct 12;677(2):280-6. doi: 10.1016/0304-4165(81)90097-0.
7
Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.单胺氧化酶-B抑制剂雷沙吉兰和铁螯合剂VK-28的双功能药物衍生物，作为治疗脑老化和老化神经退行性疾病的更有效方法。
Mech Ageing Dev. 2005 Feb;126(2):317-26. doi: 10.1016/j.mad.2004.08.023.
8
Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine 5,5-dioxides: In vitro studies and docking analysis.4,6-二氢苯并[c]吡喃[2,3-e][1,2]噻嗪 5,5-二氧化物的合成、X 射线晶体学和单胺氧化酶抑制活性：体外研究和对接分析。
Eur J Pharm Sci. 2019 Apr 1;131:9-22. doi: 10.1016/j.ejps.2019.02.007. Epub 2019 Feb 5.
9
Ligand fishing of anti-neurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B.使用固定化单胺氧化酶 B 的磁性纳米粒子从金银花中钓取抗神经退行性成分。
J Sep Sci. 2019 Mar;42(6):1289-1298. doi: 10.1002/jssc.201801255. Epub 2019 Feb 5.
10
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.一类新型强效香豆素单胺氧化酶B抑制剂的发现：7-[(3-氯苄基)氧基]-4-[(甲氨基)甲基]-2H-色烯-2-酮甲磺酸盐（NW-1772）作为一种高效、选择性、可逆且口服活性的单胺氧化酶B抑制剂的研发及生物药理学分析
J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127.

本文引用的文献

1
Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases.小憩片刻：咖啡因摄入对神经退行性疾病中微胶质细胞介导的炎症的影响
Mediators Inflamm. 2017;2017:4761081. doi: 10.1155/2017/4761081. Epub 2017 Jan 31.
2
The SH-SY5Y cell line in Parkinson's disease research: a systematic review.帕金森病研究中的SH-SY5Y细胞系：一项系统综述。
Mol Neurodegener. 2017 Jan 24;12(1):10. doi: 10.1186/s13024-017-0149-0.
3
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
新型多奈哌齐-吲哚基杂合物作为多效胆碱酯酶/单胺氧化酶抑制剂用于潜在治疗阿尔茨海默病的设计、合成、药理学评价、定量构效关系分析、分子模拟及药物代谢动力学/药物毒性预测
Eur J Med Chem. 2014 Mar 21;75:82-95. doi: 10.1016/j.ejmech.2013.12.028. Epub 2014 Jan 27.
4
Caffeine for treatment of Parkinson disease: a randomized controlled trial.咖啡因治疗帕金森病：一项随机对照试验。
Neurology. 2012 Aug 14;79(7):651-8. doi: 10.1212/WNL.0b013e318263570d. Epub 2012 Aug 1.
5
Caffeine and uric acid mediate glutathione synthesis for neuroprotection.咖啡因和尿酸通过调节谷胱甘肽合成发挥神经保护作用。
Neuroscience. 2011 May 5;181:206-15. doi: 10.1016/j.neuroscience.2011.02.047. Epub 2011 Mar 1.
6
Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms.帕金森病中咖啡因的作用：从神经保护到运动和非运动症状的管理。
J Alzheimers Dis. 2010;20 Suppl 1:S205-20. doi: 10.3233/JAD-2010-091459.
7
Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease.用于治疗帕金森病的双靶点药物，其可阻断单胺氧化酶B和腺苷A(2A)受体。
Neurotherapeutics. 2009 Jan;6(1):141-51. doi: 10.1016/j.nurt.2008.10.035.
8
Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity.多巴胺诱导的毒性在神经母细胞瘤细胞中诱导GADD45和GADD153的表达。
Neurotoxicology. 2002 Dec;23(6):675-84. doi: 10.1016/S0161-813X(02)00093-1.
9
beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine.
J Neurosci Res. 2002 Apr 1;68(1):89-96. doi: 10.1002/jnr.10193.
10
Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.男性和女性咖啡因摄入量与帕金森病风险的前瞻性研究。
Ann Neurol. 2001 Jul;50(1):56-63. doi: 10.1002/ana.1052.