Turk J Med Sci. 2019 Feb 11;49(1):93-100. doi: 10.3906/sag-1807-106.
BACKGROUND/AIM: 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collected from all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbent a ss ay.
8-OHdG was increased in patients with AECOPD compared to healthy subjects and patients with stable COPD, especially in smokers. It also increased with the GOLD stage, mMRC grade, CAT score, and group level of combined COPD assessment. Additionally, further analysis revealed that 8-OHdG was negatively correlated with FEV1, FEV1% predicted, and FEV1/FVC and positively correlated with C-reactive protein, procalcitonin, and neutrophil CD64.
8-OHdG is associated with spirometric severity, symptomatic severity, exacerbation risk, and inflammatory biomarkers in AECOPD patients, suggesting it as a promising biomarker for reflecting disease severity and guiding the choice of optimal therapeutic decision.
背景/目的：8-羟基脱氧鸟苷（8-OHdG）是氧化应激的生物标志物，与许多疾病有关。本研究旨在探讨急性加重期慢性阻塞性肺疾病（AECOPD）患者血浆 8-OHdG 水平的临床价值。
本研究共纳入 154 例受试者，包括 20 名健康志愿者、24 名稳定期 COPD 患者和 110 名 AECOPD 患者。所有受试者在入组时均采集外周血样本、人口统计学信息和临床特征。采用酶联免疫吸附法检测血浆 8-OHdG 水平。
AECOPD 患者的 8-OHdG 水平高于健康受试者和稳定期 COPD 患者，尤其是吸烟者。随着 GOLD 分期、mMRC 分级、CAT 评分和合并 COPD 评估组水平的升高，8-OHdG 水平也随之升高。此外，进一步分析显示，8-OHdG 与 FEV1、FEV1%预计值和 FEV1/FVC 呈负相关，与 C 反应蛋白、降钙素原和中性粒细胞 CD64 呈正相关。
8-OHdG 与 AECOPD 患者的肺功能严重程度、症状严重程度、加重风险和炎症生物标志物相关，提示其作为反映疾病严重程度和指导最佳治疗决策选择的有前途的生物标志物。
