Cho Su-Youn, Roh Hee-Tae
Exercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul 03722, Republic of Korea.
Division of Sports Science, College of Arts and Sports, Sun Moon University, 70 Sunmoon-ro 221 beon-gil, Tangjeong-myeon, Asan-si 31460, Republic of Korea.
Life (Basel). 2023 Sep 23;13(10):1952. doi: 10.3390/life13101952.
Exposure to particulate matter (PM) and exercise training can have antagonistic effects on inflammatory responses and the balance between pro-oxidants and antioxidants in the body. However, the underlying mechanisms of these effects remain unclear. This study aimed to investigate the effects of PM exposure and aerobic exercise training on oxidative stress, antioxidant status, and inflammation in mice of different ages. Two groups of male C57BL/6 mice, comprising forty 1-month-old and forty 12-month-old mice, were exposed to either PM or exercise training or both for 8 weeks. PM exposure led to significantly higher 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) levels ( < 0.05) and significantly lower superoxide dismutase (SOD) and catalase (CAT) activities ( < 0.05) in both age groups exposed to PM compared to the control groups. Conversely, aerobic exercise training led to significantly lower 8-OHdG, MDA, IL-1β, IL-6, and TNF-α levels ( < 0.05) and significantly higher SOD and CAT activities ( < 0.05) in both age groups receiving exercise training, compared to those exposed to PM. Moreover, young mice in the exercise training and PM group showed significantly lower 8-OHdG, MDA, and IL-1β levels ( < 0.05) and significantly higher SOD and CAT activities ( < 0.05) than young mice in the PM exposure group. However, these levels did not vary significantly between the group of old mice that either received exercise training or exposure to PM. Our results suggest that while PM exposure could cause pro-oxidant/antioxidant imbalances and inflammatory responses, regular aerobic exercise could ameliorate these negative effects, although these vary with age. Nevertheless, the antioxidant and anti-inflammatory effects of exercise were countered by PM exposure, especially in older mice.
接触颗粒物（PM）和运动训练对身体的炎症反应以及促氧化剂和抗氧化剂之间的平衡可能具有拮抗作用。然而，这些作用的潜在机制仍不清楚。本研究旨在调查PM暴露和有氧运动训练对不同年龄小鼠氧化应激、抗氧化状态和炎症的影响。两组雄性C57BL/6小鼠，每组包括40只1月龄和40只12月龄小鼠，分别接受PM暴露、运动训练或两者同时进行，为期8周。与对照组相比，暴露于PM的两个年龄组中，8-羟基脱氧鸟苷（8-OHdG）、丙二醛（MDA）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）水平显著升高（P<0.05），超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性显著降低（P<0.05）。相反，与暴露于PM的组相比，接受运动训练的两个年龄组中，8-OHdG、MDA、IL-1β、IL-6和TNF-α水平显著降低（P<0.05），SOD和CAT活性显著升高（P<0.05）。此外，运动训练和PM组中的年轻小鼠比PM暴露组中的年轻小鼠8-OHdG、MDA和IL-1β水平显著降低（P<0.05），SOD和CAT活性显著升高（P<0.05）。然而，接受运动训练或暴露于PM的老年小鼠组之间这些水平没有显著差异。我们的结果表明，虽然PM暴露可能导致促氧化剂/抗氧化剂失衡和炎症反应，但规律的有氧运动可以改善这些负面影响，尽管这些影响因年龄而异。然而，运动的抗氧化和抗炎作用被PM暴露抵消，尤其是在老年小鼠中。
