Government Medical College & Hospital, Chandigarh, India.
Panjab University, Chandigarh, India.
J Atten Disord. 2021 Mar;25(5):758-767. doi: 10.1177/1087054719829574. Epub 2019 Feb 14.
The objective of the study is to predict the early changes in electroencephalography (EEG) at 1 week and its correlation to clinical response at 6 weeks after treatment with atomoxetine in children with ADHD. In 50 children (6-14 years) with ADHD ( [5th ed.; ]), Vanderbilt ADHD Parent Rating Scale (VADPRS) and Vanderbilt ADHD Teachers Rating Scale (VADTRS) were applied at baseline, 1, 4, and 6 weeks. EEG was recorded using International 10-20 System of electrode placement at baseline and at 1 week after atomoxetine treatment. EEG changes at 1 week after atomoxetine therapy was correlated to clinical response at 6 weeks. Patients were classified as responders or nonresponders based on the VADPRS/VADTRS findings. After 1 week of treatment, responders' theta cordance values were decreased, whereas nonresponders' values didn't decrease significantly. Patients with decreased theta cordance values, especially in the left temporoparietal region, at 1 week were likely to respond to atomoxetine while those without any such change were likely to be nonresponders.
本研究旨在预测 ADHD 儿童接受托莫西汀治疗 1 周时脑电图（EEG）的早期变化及其与 6 周时临床反应的相关性。在 50 名 ADHD 儿童（6-14 岁）中（[第 5 版]），在基线、1 周、4 周和 6 周时使用 Vanderbilt ADHD 父母评定量表（VADPRS）和 Vanderbilt ADHD 教师评定量表（VADTRS）进行评估。基线和托莫西汀治疗 1 周后使用国际 10-20 系统电极放置记录 EEG。将托莫西汀治疗 1 周后的 EEG 变化与 6 周时的临床反应相关联。根据 VADPRS/VADTRS 的发现，将患者分为应答者或无应答者。治疗 1 周后，应答者的θ协调值降低，而无应答者的数值没有显著降低。1 周时θ协调值降低的患者，特别是左颞顶叶区域，可能对托莫西汀有反应，而没有任何这种变化的患者可能没有反应。
