Department of Nuclear Medicine, and.
Clin Nucl Med. 2019 May;44(5):410-411. doi: 10.1097/RLU.0000000000002494.
The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from F-FDG, F-FDS is virtually available at any PET facility with radiochemistry infrastructure.
新型 PET 探针 2-脱氧-2-F-氟-D-山梨醇（F-FDS）在动物模型中表现出良好的肾脏动力学特性。我们旨在研究其在 2 名志愿者中的成像特性。F-FDS 通过从 F-FDG 简单的 1 步还原制备而成。在肾脏动态 PET 中，皮质逐渐显影，放射性示踪剂逐渐进入实质，随后排出。未报告不良反应。与传统闪烁扫描相比，由于 PET 具有更高的时空分辨率，F-FDS PET 可以更全面地评估人体肾脏动力学。由于其可从 F-FDG 简单制备，因此任何配备放射性化学基础设施的 PET 设备均可实际应用 F-FDS。
