慢性肾脏病患者血浆 YKL-40 水平与血管内皮功能障碍的关系。
Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease.
出版信息
Turk J Med Sci. 2019 Feb 11;49(1):139-146. doi: 10.3906/sag-1804-169.
BACKGROUND/AIM: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.
MATERIALS AND METHODS
Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.
UNLABELLED
YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674 and r = –0.471, respectively).
UNLABELLED
This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements
背景/目的：我们旨在评估 YKL-40 与慢性肾脏病内皮功能障碍之间的关系。
材料和方法
纳入 29 名血液透析患者、101 名非透析（2、3、4 和 5 期 ND）慢性肾脏病（CKD）患者和 38 名健康个体作为对照组。通过 ELISA 测定 YKL-40 水平。通过肱动脉血流介导的扩张百分比（FMD）间接测量内皮功能障碍。
未标记
CKD 患者的 YKL-40 水平高于对照组，血液透析患者的水平最高（P=0.001）。非透析性 CKD 患者的 FMD 值较低，血液透析患者的 FMD 值最低（P=0.001）。YKL-40 与 eGFR 和 FMD 值呈负相关（r=-0.674 和 r=-0.471）。
未标记
本研究表明，YKL-40 随着 CKD 分期的增加而增加，与 FMD 测量值呈负相关。
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