Promberger Regina, Hermann Michael, Ott Johannes
a Department of Surgery, Kaiserin Elisabeth Spital, Huglgasse 1-3, 1150 Vienna, Austria.
b Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Expert Rev Endocrinol Metab. 2012 Mar;7(2):175-179. doi: 10.1586/eem.12.3.
Hashimoto's thyroiditis (HT) is one of the most common autoimmune endocrine disorders and often leads to hypothyroidism. It has been shown to substantially affect a patient's quality of life. Associated conditions and diseases were thought to be attributable to hypothyroidism. Yet, many patients still suffer from various symptoms even though all thyroid parameters are within the normal range. Independently of thyroid gland function, HT is associated with a wide range of organ-specific and non-organ-specific autoimmune disorders, as well as other diseases, including neuropsychological/psychiatric deficits, decreased left ventricular performance, disorders of the gut, fibromyalgia and reproductive health issues, among others. The underlying pathomechanisms remain unclear. Future treatment options might include thyroidectomy, selenium administration, prophylactic levothyroxine supplementation and dehydroepiandrosterone. However, further research is warranted to clarify the main pathophysiologic implications of thyroid autoimmunity and also to establish treatment options for euthyroid patients who suffer from HT-related symptoms and diseases.
桥本甲状腺炎（HT）是最常见的自身免疫性内分泌疾病之一，常导致甲状腺功能减退。已证明它会严重影响患者的生活质量。相关病症和疾病曾被认为归因于甲状腺功能减退。然而，许多患者即使所有甲状腺参数都在正常范围内，仍会出现各种症状。独立于甲状腺功能，HT与多种器官特异性和非器官特异性自身免疫性疾病以及其他疾病有关，包括神经心理/精神缺陷、左心室功能下降、肠道疾病、纤维肌痛和生殖健康问题等。其潜在的发病机制仍不清楚。未来的治疗选择可能包括甲状腺切除术、补充硒、预防性补充左甲状腺素和脱氢表雄酮。然而，有必要进一步研究以阐明甲状腺自身免疫的主要病理生理意义，并为患有HT相关症状和疾病的甲状腺功能正常患者确定治疗方案。
