Sudame Atul, Kandasamy Ganeshlenin, Maity Dipak
Department of Mechanical Engineering, Shiv Nadar University, Dadri 201314, UP, India.
J Nanosci Nanotechnol. 2019 Jul 1;19(7):3991-3999. doi: 10.1166/jnn.2019.16326.
Superparamagnetic iron oxide nanoparticles (SPIONs) have found applications in the magnetic fluid hyperthermia (MFH) due to their unique magnetic properties, chemical stability and biocompatibility. However, challenges exist in attaining high heating efficiencies of the SPIONs under the applied alternating magnetic fields below Hergt's biological safety limit. Here, we present synthesis of single surfactant (pyromellitic acid (PMA)/2-aminoterephthalic acid (ATA)) and dual surfactants (PMA-ATA) coated SPIONs via chemical co-precipitation method and characterization to determine their phase purity, surface coatings and particle sizes. The hydrodynamic sizes/zeta potentials values of the SPIONs were determined for studying their water-dispersibility. Finally, the impact of heating on specific absorption rate (SAR) and intrinsic loss of power (ILP) were determined. SPIONs were found to exhibit magnetite phase and particle sizes in the range of 9-10 nm, good water dispersibility with (i) hydrodynamic diameters ranging from 190-304 nm and (ii) zeta potentials ranging from -38 mV to -49 mV. The ATA and PMA-ATA coated SPIONs showed better time-dependent temperature rise that resulted in higher heating efficacies-i.e., SAR and ILP values ranging from 58.6-79.5 W/g and 1.7-2.3 nHm²/Kg, respectively as compared to the PMA coated SPIONs. Thus, ATA and PMA-ATA coated SPIONs were found to be very promising candidates for their usage in MFH applications.
超顺磁性氧化铁纳米颗粒（SPIONs）因其独特的磁性、化学稳定性和生物相容性，已在磁流体热疗（MFH）中得到应用。然而，在低于赫格特生物安全极限的外加交变磁场下，要实现SPIONs的高加热效率仍存在挑战。在此，我们通过化学共沉淀法合成了单表面活性剂（均苯四甲酸（PMA）/2-氨基对苯二甲酸（ATA））和双表面活性剂（PMA-ATA）包覆的SPIONs，并进行了表征，以确定其相纯度、表面包覆情况和粒径。测定了SPIONs的流体动力学尺寸/ζ电位值，以研究其水分散性。最后，确定了加热对比吸收率（SAR）和固有功率损耗（ILP）的影响。发现SPIONs呈现磁铁矿相，粒径在9-10nm范围内，具有良好的水分散性，（i）流体动力学直径范围为190-304nm，（ii）ζ电位范围为-38mV至-49mV。与PMA包覆的SPIONs相比，ATA和PMA-ATA包覆的SPIONs表现出更好的随时间的温度升高，从而导致更高的加热效率，即SAR和ILP值分别在58.6-79.5W/g和1.7-2.3nHm²/Kg范围内。因此，发现ATA和PMA-ATA包覆的SPIONs是用于MFH应用的非常有前景的候选材料。
