基于二硫化钼-氧化石墨烯负载磁性纳米粒子的三维分级框架用于水样中氟喹诺酮类抗生素的富集。
Three-dimensional hierarchical frameworks based on molybdenum disulfide-graphene oxide-supported magnetic nanoparticles for enrichment fluoroquinolone antibiotics in water.
机构信息
Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China; Tianjin Key Laboratory of Molecular Optoelectronics, Department of Chemistry, Tianjin University, Tianjin 300072, China.
出版信息
J Chromatogr A. 2019 May 24;1593:1-8. doi: 10.1016/j.chroma.2019.02.005. Epub 2019 Feb 8.
Recently, water pollution caused by antibiotics is rapidly increasing. Thus, developing efficient, fast and sensitive detection methods for environmental antibiotics monitoring are still remaining elusive. Herein, a method for antibiotics analysis including lecofloxacin, pazcofloxacin and gatifloxacin in water by high performance liquid chromatography (HPLC) using molybdenum disulfide-graphene oxide-supported magnetic nanoparticles (FeO/GO/MoS) as the adsorbent of magnetic solid-phase extraction was developed. The as-prepared magnetic FeO/GO/MoS nanocomposite exhibited good enrichment capability toward fluoroquinolone antibiotics and the analytes were absorbed within a short time ca. 2 min. The main drive forces of FeO/GO/MoS nanocomposite and antibiotics were most likely attributed to hydrogen bonding and electrostatic attraction. A sensitive and effective MSPE-HPLC method was developed with low detection limits (LODs) ranging from 0.25 to 0.50 ng mL. The recoveries obtained from the analysis of water sample were between 85.6% and 106.1% with relative standard deviations (RSDs, n = 5) lower than 9.5%. The developed method has a good potential for the analysis of organic contaminants in water with low cost and high sensitivity. Therefore, this finding is a promising strategy for designing high efficiency and fast antibiotics detection system.
最近，抗生素引起的水污染迅速增加。因此，开发高效、快速和灵敏的环境抗生素监测检测方法仍然难以实现。在此，本文开发了一种通过高效液相色谱法（HPLC）分析水中包括左氧氟沙星、帕珠沙星和加替沙星在内的抗生素的方法，该方法使用二硫化钼-氧化石墨烯负载磁性纳米粒子（FeO/GO/MoS）作为磁性固相萃取的吸附剂。所制备的磁性 FeO/GO/MoS 纳米复合材料对氟喹诺酮类抗生素具有良好的富集能力，分析物在短时间内（约 2 分钟）被吸收。FeO/GO/MoS 纳米复合材料和抗生素的主要驱动力很可能归因于氢键和静电吸引。建立了一种灵敏有效的 MSPE-HPLC 方法，检测限（LOD）范围为 0.25-0.50ng/mL。水样分析的回收率在 85.6%到 106.1%之间，相对标准偏差（RSD，n=5）低于 9.5%。该方法具有低成本和高灵敏度分析水中有机污染物的良好潜力。因此，这一发现为设计高效快速抗生素检测系统提供了一种有前途的策略。
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