Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Hypertens Res. 2019 Jul;42(7):1029-1035. doi: 10.1038/s41440-019-0228-4. Epub 2019 Feb 14.
Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We examined serum soluble corin using immunoassays in 962 men (mean age, 53 years) and 1536 women (mean age, 54 years) free of cardiovascular disease. Logistic regression was applied to examine the association between soluble corin and MetS in men and women. The results showed that participants in the 3rd and 4th quartiles of serum soluble corin had 1.99 (95% CI: 1.32-3.00) and 3.84 (95% CI: 2.54-5.83) times the risk of having MetS for men and 1.48 (95% CI: 1.06-2.06) and 1.53 (95% CI: 1.10-2.12) times the risk of having MetS for women compared to those in the lowest quartile. The magnitude of the association between serum soluble corin and MetS was significantly stronger for men than for women (P < 0.001). These results indicated that soluble corin was significantly associated with MetS, and this association was stronger for men than for women. Corin may contribute to cardiometabolic risks differently between men and women and thereby accounting, at least partly, for the sex difference in cardiovascular risk.
可溶性心钠肽素与心血管疾病及其危险因素相关，但它是否与代谢综合征（MetS），即一组心血管代谢疾病相关，尚不清楚。我们旨在研究中国男性和女性中可溶性心钠肽素与 MetS 的相关性。我们使用免疫分析法检测了 962 名男性（平均年龄 53 岁）和 1536 名女性（平均年龄 54 岁）无心血管疾病患者的血清可溶性心钠肽素。我们应用 logistic 回归分析来研究男性和女性中可溶性心钠肽素与 MetS 之间的关系。结果表明，血清可溶性心钠肽素第 3 和第 4 四分位组的男性发生 MetS 的风险是第 1 四分位组的 1.99 倍（95%CI：1.32-3.00）和 3.84 倍（95%CI：2.54-5.83），女性则是 1.48 倍（95%CI：1.06-2.06）和 1.53 倍（95%CI：1.10-2.12）。与最低四分位组相比，血清可溶性心钠肽素与 MetS 之间的关联在男性中明显强于女性（P<0.001）。这些结果表明，可溶性心钠肽素与 MetS 显著相关，且这种相关性在男性中强于女性。心钠肽素可能在男性和女性之间对心血管代谢风险的贡献方式不同，从而至少部分解释了心血管风险的性别差异。
