用于耐药性尿路感染的呋喃妥因和磷霉素：应对新问题的老药
Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems.
作者信息
Gardiner Bradley J, Stewardson Andrew J, Abbott Iain J, Peleg Anton Y
机构信息
Department of Infectious Disease, Alfred Health and Central Clinical School, Monash University, Melbourne.
Department of Medical Microbiology and Infectious Diseases, Research and Development Unit, Erasmus Medical Centre, Rotterdam, The Netherlands.
出版信息
Aust Prescr. 2019 Feb;42(1):14-19. doi: 10.18773/austprescr.2019.002. Epub 2019 Feb 1.
Abstract
Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women
摘要
单纯性尿路感染是社区中抗生素使用最常见的指征之一。然而，可引起该感染的革兰氏阴性菌对抗生素的耐药性越来越强。许多多重耐药菌对两种老抗生素呋喃妥因和磷霉素仍敏感。与新型药物相比，它们的优势在于尿液中浓度高且毒性极小。对于因耐药菌引起的单纯性尿路感染患者，磷霉素是一种潜在的治疗选择。呋喃妥因可能更有效，可用于孕妇的泌尿系统感染。
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