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Fed Pract. 2015 Feb;32(2):36-41.
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Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence.海洛因依赖患者中低剂量美沙酮相关性 QTc 延长易感性的性别差异。
J Cardiovasc Electrophysiol. 2012 May;23(5):527-33. doi: 10.1111/j.1540-8167.2011.02231.x. Epub 2011 Dec 2.
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J Am Coll Cardiol. 2011 Feb 15;57(7):794-801. doi: 10.1016/j.jacc.2010.09.064.
5
Retrospective analysis of low-dose methadone and QTc prolongation in chronic pain patients.慢性疼痛患者低剂量美沙酮与 QTc 间期延长的回顾性分析。
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6
Onsite QTc interval screening for patients in methadone maintenance treatment.美沙酮维持治疗患者的 QTc 间期现场筛查。
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The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.口服美沙酮对晚期癌症患者 QTc 间期的影响：一项前瞻性初步研究。
J Palliat Med. 2010 Jan;13(1):33-8. doi: 10.1089/jpm.2009.0184.
8
Prevalence and clinical relevance of corrected QT interval prolongation during methadone and buprenorphine treatment: a mortality assessment study.美沙酮和丁丙诺啡治疗期间校正QT间期延长的患病率及临床相关性：一项死亡率评估研究。
Addiction. 2009 Jun;104(6):993-9. doi: 10.1111/j.1360-0443.2009.02549.x. Epub 2009 Apr 9.
9
Methadone-associated Q-T interval prolongation and torsades de pointes.美沙酮相关的Q-T间期延长和尖端扭转型室速。
Am J Health Syst Pharm. 2009 May 1;66(9):825-33. doi: 10.2146/ajhp070392.
10
QTc interval screening in methadone treatment.美沙酮治疗中的QTc间期筛查
Ann Intern Med. 2009 Mar 17;150(6):387-95. doi: 10.7326/0003-4819-150-6-200903170-00103. Epub 2009 Jan 19.

退伍军人人群中美沙酮诱导的QTc间期延长的评估。

Evaluation of Methadone-Induced QTc Prolongation in a Veteran Population.

作者信息

Heesch Chelsie B, Copfer Amy E, Davis Stephanie J, Edwards Bryan W

机构信息

is a mental health clinical pharmacy specialist, is an intensive care and cardiology clinical pharmacist, is a program manager for education and clinical services, and is an emergency department clinical pharmacist, all at the Southern Arizona VA Health Care System in Tucson.

出版信息

Fed Pract. 2015 Feb;32(2):36-41.

PMID:30766045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6363331/
Abstract

Understanding the effects of methadone on the QTc interval in a veteran patient population using the drug at lower doses for pain may help clinicians develop strategies and protocols for safe use.

摘要

了解美沙酮在退伍军人患者群体中以较低剂量用于止痛时对QTc间期的影响，可能有助于临床医生制定安全用药的策略和方案。