HMGA1基因变体IVS5-13insC与胰岛素抵抗和2型糖尿病相关：一项更新的荟萃分析。

HMGA1 variant IVS5-13insC is associated with insulin resistance and type 2 diabetes: an updated meta-analysis.

作者信息

Liu Yancheng, Zheng Liting, Kong Hao, Wang Qinglu, Tian Xuewen

机构信息

Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Qilu Medical University, Zibo, 255213, China.

Department of Vascular, Thyroid and Breast Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, China.

出版信息

Afr Health Sci. 2018 Dec;18(4):865-872. doi: 10.4314/ahs.v18i4.4.

DOI:10.4314/ahs.v18i4.4

PMID:30766549

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6354845/

Abstract

BACKGROUND

High-mobility group A1 (HMGA1) polymorphism has been suspected as a gene variant associated with type 2 diabetes (T2D). However, conflicting outcomes have been reported.

OBJECTIVE

This meta-analysis aimed to predict the association between the HMGA1 variant IVS5-13insC and T2D.

METHODS

Statistical analyses were performed using Stata/SE 12.0 software.

RESULTS

A total of 11 case-control studies in 6 articles were included. Results suggested that the HMGA1 variant IVS5-13insC was associated with an increased risk of insulin resistance (OR = 0.61, 95% CI 0.56 to 0.66, P < 0.0001), T2D (OR = 0.67, 95% CI 0.61 to 0.73, P < 0.0001), particularly for Caucasians with increased risks of T2D (OR = 0.56, 95% CI 0.49 to 0.65, P < 0.0001) compared with wild-type subjects.

CONCLUSION

This meta-analysis indicated that the HMGA1 variant IVS5-13insC can be a risk factor of T2D development, particularly among Caucasians. Significant risks were also found (Asian: OR = 0.74, 95% CI: 0.63 to 0.86, P < 0.0001, Hispanic-American: OR = 0.81, 95% CI: 0.65 to 1.01, P < 0.0001) in non-Caucasian population. However, ethnical studies should be conducted to reveal whether the HMGA1 variant IVS5-13insC is associated with an increased risk of T2D.

摘要

背景

高迁移率族蛋白A1（HMGA1）基因多态性被怀疑是与2型糖尿病（T2D）相关的基因变异。然而，已报道的结果相互矛盾。

目的

本荟萃分析旨在预测HMGA1基因变异IVS5-13insC与T2D之间的关联。

方法

使用Stata/SE 12.0软件进行统计分析。

结果

纳入了6篇文章中的11项病例对照研究。结果表明，HMGA1基因变异IVS5-13insC与胰岛素抵抗风险增加相关（OR = 0.61，95%CI 0.56至0.66，P < 0.0001），与T2D相关（OR = 0.67，95%CI 0.61至0.73，P < 0.0001），特别是与野生型受试者相比，T2D风险增加的白种人（OR = 0.56，95%CI 0.49至0.65，P < 0.0001）。

结论

本荟萃分析表明，HMGA1基因变异IVS5-13insC可能是T2D发生的危险因素，特别是在白种人中。在非白种人群中也发现了显著风险（亚洲人：OR = 0.74，95%CI：0.63至0.86，P < 0.0001，西班牙裔美国人：OR = 0.81，95%CI：0.65至1.01，P < 0.0001）。然而，应进行种族研究以揭示HMGA1基因变异IVS5-13insC是否与T2D风险增加相关。