Nithin Kumar U, Sridhar M G, Srilatha K, Habebullah S
Department of Biochemistry.
Department of Obstetrics and Gynecology, Jawaharlal Institute of Post graduate Medical Education and Research, Puducherry - 605006.
Afr Health Sci. 2018 Dec;18(4):972-978. doi: 10.4314/ahs.v18i4.17.
Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB.
To estimate and compare serum prolactin, Cancer Antigen 125 (CA-125), Cancer Antigen 15-3 (CA15-3), and Carcino embryonic antigen (CEA) levels in patients with endometrial cancer and abnormal uterine bleeding; To evaluate the role of these markers in diagnosing endometrial cancer.
Thirty eight patients with endometrial cancer and 40 patients with AUB were recruited in this study. Serum prolactin, CA 125, CEA, and CA 15-3 levels were estimated in both groups.
The levels of CA 15-3, CA 125, CEA, and prolactin were increased in endometrial carcinoma patients, on comparison with AUB patients. CA 125 alone was found to be a better marker to detect endometrial cancer with 52.63% sensitivity, 80.00% specificity.
As individual tumor marker, serum CA 125 has the ability to detect endometrial cancer in patients with abnormal uterine bleeding.
由于生活方式的改变和肥胖，印度子宫内膜癌的发病率正在上升。鉴于局限于子宫的癌症5年生存率良好，因此需要一种血清肿瘤标志物用于早期诊断。本研究旨在确定一种能区分子宫内膜癌和异常子宫出血（AUB）的肿瘤标志物，因为子宫内膜癌的常见表现就是AUB。
评估并比较子宫内膜癌患者和异常子宫出血患者的血清催乳素、癌抗原125（CA - 125）、癌抗原15 - 3（CA15 - 3）和癌胚抗原（CEA）水平；评估这些标志物在诊断子宫内膜癌中的作用。
本研究招募了38例子宫内膜癌患者和40例AUB患者。对两组患者的血清催乳素、CA 125、CEA和CA 15 - 3水平进行了评估。
与AUB患者相比，子宫内膜癌患者的CA 15 - 3、CA 125、CEA和催乳素水平升高。发现单独CA 125是检测子宫内膜癌的较好标志物，敏感性为52.63%，特异性为80.00%。
作为单一肿瘤标志物，血清CA 125能够在异常子宫出血患者中检测出子宫内膜癌。
