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高效的肺癌靶向药物递送：一种纳米颗粒/间充质干细胞系统。

Efficient lung cancer-targeted drug delivery a nanoparticle/MSC system.

作者信息

Wang Xusheng, Chen Haiyan, Zeng Xiaowei, Guo Wenpeng, Jin Yu, Wang Shan, Tian Ruiyun, Han Yanjiang, Guo Ling, Han Jimin, Wu Yaojiong, Mei Lin

机构信息

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.

Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China.

出版信息

Acta Pharm Sin B. 2019 Jan;9(1):167-176. doi: 10.1016/j.apsb.2018.08.006. Epub 2018 Sep 3.

DOI:10.1016/j.apsb.2018.08.006
PMID:30766788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6362298/
Abstract

Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel (DTX) in NP, delivered MSC accumulated in the lung. Both MSC/A549 cell experiments and MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases.

摘要

低靶向效率限制了纳米颗粒在癌症治疗中的应用。全身输注后间充质干细胞（MSC）滞留在肺部这一事实对细胞治疗目的而言是一个不利因素。在此，我们通过用抗癌药物负载纳米颗粒（NP），将MSC用作肺癌靶向药物递送载体。MSC显示出比成纤维细胞更高的药物摄取能力。此外，MSC在兔和猴体内均表现出主要的肺部滞留。IR-780染料是一种用于代表NP中的多西他赛（DTX）的荧光探针，其递送的MSC在肺部积聚。MSC/A549细胞实验和MSC/肺癌实验均验证了NP在MSC与癌细胞之间的细胞间转运。 检测表明，MSC/NP/DTX药物递送系统发挥的原发性肿瘤抑制效率与NP/DTX药物系统相似。总体而言，MSC/NP药物递送系统在用于治疗肺癌和其他肺部相关疾病的肺部靶向药物递送方面具有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/50d613ad8f86/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/f9388e6854ba/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/ee56a9288aaf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/5f967cdc47bf/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/b5a923c8b72c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/dbce42f1f33e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/50d613ad8f86/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/f9388e6854ba/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/ee56a9288aaf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/5f967cdc47bf/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/b5a923c8b72c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/dbce42f1f33e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/6362298/50d613ad8f86/gr5.jpg

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