Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.
Department of Imaging, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Brain Behav. 2019 Mar;9(3):e01220. doi: 10.1002/brb3.1220. Epub 2019 Feb 14.
To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non-RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients.
Polysomnography (PSG) was performed to confirm and exclude RBD. Fifteen iRBD patients, 12 PD with RBD patients, and 23 matched nRBD healthy control subjects were enrolled. Subjective sleep and neuropsychological evaluations were performed.
No differences were found in the subjective sleep among the three groups. Compared to the nRBD subjects, iRBD patients showed higher PLMI, the PD with RBD patients showed an increased proportion of N1 sleep, a decreased proportion of N2 and N3 sleep, and an increased periodic leg movement index. The iRBD patients performed worse on RCFT time than the nRBD subjects, the PD with RBD patients performed worse than the nRBD subjects on the following evaluations: the Mini-Mental State Examination; auditory verbal learning test (AVLT); Rey Complex Figure Test (RCFT) time, Clock drawing test (CDT); delay memory score of RCFT; Symbol digit modalities test (SDMT); Trail Making Test (TMT); and Stroop Test B and C, all significant changes (all p < 0.05). Furthermore, in RBD patients, lower sleep efficiency was correlated with decreased SDMT scores (r = 0.694, p < 0.01), longer time on the TMT A (r = -0.589, p < 0.01), and lower city fluency test scores(r = 0.556, p < 0.01). Less total sleep time was correlated with lower RCFT scores (r = 0.392, p = 0.043), longer time on the TMT A (r = -0.417, p = 0.031), and lower city fluency test scores (r = 0.405, p = 0.036).
PD with RBD patients suffered from abnormal sleep architecture and extensive cognition dysfunction. Decreased total sleep time and sleep efficiency may contribute to cognitive deterioration in RBD patients.
比较快速眼动睡眠行为障碍（RBD）患者与非 RBD（nRBD）健康对照组的睡眠特征和认知功能，并确定 RBD 患者睡眠与认知之间的相关性。
进行多导睡眠图（PSG）以确认和排除 RBD。纳入 15 例 iRBD 患者、12 例伴有 RBD 的 PD 患者和 23 例匹配的 nRBD 健康对照组。进行主观睡眠和神经心理学评估。
三组之间的主观睡眠无差异。与 nRBD 受试者相比，iRBD 患者的 PLMI 更高，PD 伴 RBD 患者的 N1 睡眠比例增加，N2 和 N3 睡眠比例减少，周期性肢体运动指数增加。iRBD 患者在 RCFT 时间上的表现劣于 nRBD 受试者，PD 伴 RBD 患者在以下评估中表现劣于 nRBD 受试者：简易精神状态检查；听觉词语学习测试（AVLT）； Rey 复杂图形测试（RCFT）时间、画钟测验（CDT）；RCFT 延迟记忆评分；符号数字模式测试（SDMT）；连线测试（TMT）；Stroop 测试 B 和 C，所有变化均有统计学意义（均 p<0.05）。此外，在 RBD 患者中，较低的睡眠效率与 SDMT 评分降低相关（r=0.694，p<0.01），TMT A 时间延长（r=-0.589，p<0.01），城市流畅性测验评分降低（r=0.556，p<0.01）。总睡眠时间减少与 RCFT 评分降低相关（r=0.392，p=0.043），TMT A 时间延长（r=-0.417，p=0.031），城市流畅性测验评分降低（r=0.405，p=0.036）。
PD 伴 RBD 患者存在异常睡眠结构和广泛的认知功能障碍。总睡眠时间和睡眠效率降低可能导致 RBD 患者认知功能恶化。
