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育龄期癫痫女性的协同照护

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

机构信息

1 Monash University, Melbourne, Australia.

2 New York University School of Medicine, New York, New York.

出版信息

J Womens Health (Larchmt). 2019 Mar;28(3):339-345. doi: 10.1089/jwh.2018.7506. Epub 2019 Feb 15.

Abstract

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. This includes the impact AED therapies have on pregnancy, such as risk of teratogenicity, changes to AED clearance rates during pregnancy and postpartum, and risk of seizure worsening while pregnant; interactions of hormonal contraceptives and AEDs; side effects of AED treatment on hormonal systems and sexual functioning; and matters of fertility and infertility treatments. The current editorial discusses these relationships between AED choice, dose, and family planning matters for women with epilepsy in their childbearing years to support the collaboration of care between her neurologist, OBGYN, and internist.

摘要

超过 50 万名育龄妇女患有癫痫,其中许多人在生育期的某个阶段需要计划生育护理。避孕、怀孕、生育和性功能等问题都不同程度地受到抗癫痫药物(AED)治疗癫痫的影响,需要由女性的神经科医生进行积极管理。重要的是,女性的妇产科医生(OBGYN)和内科医生了解他们的护理可能与她的癫痫护理相关,以及如何与她的神经科医生成功共同管理,这包括 AED 疗法对怀孕的影响,如致畸风险、怀孕和产后 AED 清除率的变化,以及怀孕期间癫痫恶化的风险;激素避孕药和 AED 之间的相互作用;AED 治疗对激素系统和性功能的副作用;以及生育和不孕治疗的问题。本期社论讨论了育龄期癫痫女性的 AED 选择、剂量和计划生育问题之间的关系,以支持她的神经科医生、OBGYN 和内科医生之间的护理合作。

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