Joshi J G, Clauberg M
Department of Biochemistry, University of Tennessee, Knoxville 37996-0840.
Biofactors. 1988 Oct;1(3):207-12.
Ferritin is the major protein for iron storage and iron detoxification. Since non-ferrous metals, such as aluminum, beryllium and zinc, are bound both in vivo and in vitro, ferritin is implicated as a general metal ion donor and detoxicant. The role of ferritin in Al and Be toxicity is discussed. During iron release ferritin produces free radicals which are involved in phosphoprotein inactivation, lipid peroxidation and, possibly, the general aging process. Conversely, during iron loading oxidative energy in the form of electrons and protons is given off. The different subunit compositions of ferritin, termed isoferritins, are, at least in part, involved with the multifunctionality of this protein.
铁蛋白是铁储存和铁解毒的主要蛋白质。由于铝、铍和锌等有色金属在体内和体外均能与之结合，铁蛋白被认为是一种通用的金属离子供体和解毒剂。本文讨论了铁蛋白在铝和铍毒性中的作用。在铁释放过程中，铁蛋白会产生自由基，这些自由基参与磷蛋白失活、脂质过氧化反应，并且可能参与一般的衰老过程。相反，在铁负载过程中，会以电子和质子的形式释放氧化能。铁蛋白的不同亚基组成，即所谓的异铁蛋白，至少部分地与该蛋白质的多功能性有关。
