通过 SOF 介导的醇与芳基叠氮化物的脱水环加成反应，实现无过渡金属区域选择性构建 1,5-二芳基-1,2,3-三唑
Transition-metal-free regioselective construction of 1,5-diaryl-1,2,3-triazoles through dehydrative cycloaddition of alcohols with aryl azides mediated by SOF.
机构信息
State Key Laboratory of Silicate Materials for Architectures, School of Chemistry, Chemical Engineering and Life Science Wuhan University of Technology, Wuhan 430070, China.
出版信息
Chem Commun (Camb). 2019 Feb 28;55(19):2845-2848. doi: 10.1039/c8cc09693g.
A novel, simple and practical method for mild, efficient, cost-effective and regioselective synthesis of highly valuable 1,5-diaryl-1,2,3-triazoles was achieved through dehydrative annulation of readily available alcohols with aryl azides. The reaction proceeded at room temperature, without any metal catalysts, exhibiting excellent compatibility to a large variety of functional groups (>50 examples), resulting in up to quantitative yields.
通过易得的醇与芳基叠氮化物的脱水环化反应，实现了一种新颖、简单、实用的方法，用于温和、高效、经济且区域选择性地合成高价值的 1,5-二芳基-1,2,3-三唑。该反应在室温下进行，无需任何金属催化剂，对各种官能团具有优异的兼容性（>50 个实例），最高产率可达定量。
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