索非布韦介导的将醛（RCHO）转化为氰胺（RNHCN）的一锅串联反应过程。
SOF-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN).
作者信息
Zhao Yiyong, Wei Junjie, Ge Shuting, Zhang Guofu, Ding Chengrong
机构信息
College of Chemical Engineering, Zhejiang University of Technology Hangzhou 310014 People's Republic of China
Zhejiang Emission Trading Center Hangzhou 310014 People's Republic of China.
出版信息
RSC Adv. 2020 May 4;10(29):17288-17292. doi: 10.1039/d0ra02631j. eCollection 2020 Apr 29.
A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.
开发了一种简单、温和且实用的级联过程，用于将醛直接转化为氰胺，该过程具有广泛的底物范围和良好的官能团耐受性。该方法能够以一锅法、原子经济性和步骤经济性的方式，使用绿色氮源，将容易获得、廉价且丰富的醛转化为高价值的氰胺。该方案将成为在各种复杂分子中引入氰胺部分的有力工具。
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