Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Department of Biomedical and Specialty Surgical Sciences-Clinical psychiatric division, University of Ferrara, Ferrara, Italy.
PLoS One. 2019 Feb 15;14(2):e0211938. doi: 10.1371/journal.pone.0211938. eCollection 2019.
This study aims to describe factors associated to treatment continuity and psychiatric relapses in patients treated with Long Acting Injectable antipsychotics (LAIs) in Bologna Community Mental Health Centers (CMHCs).
New LAI treatments administered between July 1, 2010 and June 30, 2015 in CMHCs were selected. The cohort was followed-up for 6 months; predictors of continuity and psychiatric admissions were investigated by using logistic regression- and Cox- analysis respectively.
Among the cohort of 1 070 patients, only 222 (21%) continued LAI treatment during the follow-up. LAI continuity was higher with first generation agents (OR: 1.71, 95%CI 1.18-2.49) and in case of previous psychiatric hospitalizations (OR 2.00, 95%CI 1.47-2.74). Incidence of psychiatric hospital admissions showed a sharp reduction in the follow-up compared with 6-month period before initiation (from 458 to 212), and was associated with previous psychiatric hospitalizations (HR 3.20, 95%CI 2.22-4.59), immigration (HR 3.13, 95%CI 1.28-7.69) and LAI discontinuation (HR 1.14, 95%Cl 1.01-1.97).
Psychiatric hospital admission before LAI initiation was the main predictor both of LAI continuity and hospitalization during the follow-up.
本研究旨在描述博洛尼亚社区心理健康中心（CMHC）接受长效注射抗精神病药物（LAI）治疗的患者中，与治疗连续性和精神复发相关的因素。
选择 2010 年 7 月 1 日至 2015 年 6 月 30 日期间在 CMHC 中进行的新 LAI 治疗。对队列进行了 6 个月的随访；使用逻辑回归和 Cox 分析分别研究了连续性和精神科住院的预测因素。
在队列的 1070 名患者中，只有 222 名（21%）在随访期间继续接受 LAI 治疗。第一代药物（OR：1.71，95%CI 1.18-2.49）和之前的精神病院住院（OR 2.00，95%CI 1.47-2.74）与 LAI 连续性更高。与起始前的 6 个月相比，随访期间精神科住院的发生率明显降低（从 458 例降至 212 例），与之前的精神病院住院（HR 3.20，95%CI 2.22-4.59）、移民（HR 3.13，95%CI 1.28-7.69）和 LAI 停药（HR 1.14，95%Cl 1.01-1.97）有关。
LAI 起始前的精神病院住院是 LAI 连续性和随访期间住院的主要预测因素。
