Titov V N, Aripovsky A V, Sazhina N N, Evteeva N M, Kalinin A V, Ivanov G A
National Medical Research Center of Cardiology of the Ministry of Health of Russia, 121552, Moscow.
State Research Center for Applied Microbiology and Biotechnology, Gossanepidnadzor RF, 142279, Obolensk, Moscow Region.
Klin Lab Diagn. 2018;63(10):596-604. doi: 10.18821/0869-2084-2018-63-10-596-604.
According to the phylogenetic theory of general pathology, seven biological functions have been formed over billions of years. 1. biological function of trophology, nutrition; 2. homeostasis function; 3. biological function of endoecology; 4. function of adaptation; 5. function of the continuation of the species; 6. function of locomotion and 7. cognitive biological function, including intelligence. Millions of years in life consistently in the waters of several oceans, all the ancestors of man were carnivorous (Carnivores), fish-eating mammals. When the ocean retreated and the carnivorous (fish-eating) were on land, each individual privatized a "piece" of the ocean. Animals transformed it ito a pool of intercellular medium in vivo. The biological role of the late in the phylogeny of insulin is the formation of new biological functions in vivo. The action of insulin has transformed the carnivorous (fish-eating) ocean into herbivorous (Herbivores) species on land. There was it by synthesis in vivo from exogenous glucose of fatty acids (FA). Regulatory action of insulin was the directed conversion of exogenous glucose into ω-6 C18: 1 cis-oleic FA. Insulin late in phylogeny expressed the synthesis of new, conjugated enzymes: it is palmitoyl-CoA-elongase and stearyl-CoAdesaturase. Two enzymes synthesized FAs along the way: synthesized in situ de novo, from exogenous glucose, C16: 0 palmitic acid → C18: 0 stearic acid → ω-6 C18: 1 cis-oleic acid without accumulation of stearic FA. Insulin is not converted into an oleic FA exogenous palmitic acid from carnivorous food. On land, the action of insulin transformed the species Homo sapiens, into a herbivore, but with carnivorous, fish-eating, past. The idea of a person as omnivorous (Omnivor) - nonsense; such forms of nature did not form. Violation of the function of nutrition, the biological reaction of exotrophy (external nutrition), is the etiological and pathogenetic basis of the seven metabolic pandemics, the diseases of civilization. 1. Atherosclerosis and atheromatosis; 2. metabolic arterial hypertension; 3. metabolic syndrome; 4. obesity; 5. syndrome of insulin resistance; 6. non-alcoholic fatty liver disease and 7. endogenous hyperuricemia. The primary prevention of metabolic pandemics in the biological function of nutrition, in the biological reactions of exo-and endotrophy, will allow us to understand the theoretical bases and implementation of preventive actions that will determine the characteristics of nutrition in the future.
根据普通病理学的系统发育理论，在数十亿年的时间里形成了七种生物学功能。1. 营养生理学的生物学功能，即营养；2. 稳态功能；3. 内生态学的生物学功能；4. 适应功能；5. 物种延续功能；6. 运动功能；7. 认知生物学功能，包括智力。数百万年来，人类的所有祖先都生活在几大洋的水域中，都是肉食性（食肉动物）、以鱼为食的哺乳动物。当海洋退去，这些肉食性（以鱼为食）动物来到陆地时，每个个体都将一片海洋“私有化”。动物将其转化为体内的细胞间介质池。胰岛素在系统发育后期的生物学作用是在体内形成新的生物学功能。胰岛素的作用将肉食性（以鱼为食）的海洋生物转变为陆地上的草食性（食草动物）物种。这是通过体内从外源葡萄糖合成脂肪酸（FA）实现的。胰岛素的调节作用是将外源葡萄糖定向转化为ω-6 C18:1顺式油酸。胰岛素在系统发育后期表达了新的共轭酶的合成：即棕榈酰辅酶A延长酶和硬脂酰辅酶A去饱和酶。这两种酶沿途合成脂肪酸：从外源葡萄糖原位从头合成，C16:0棕榈酸→C18:0硬脂酸→ω-6 C18:1顺式油酸，而不会积累硬脂酸。胰岛素不会将肉食性食物中的外源棕榈酸转化为油酸。在陆地上，胰岛素的作用将智人物种转变为草食动物，但有着肉食性、以鱼为食的过去。将人视为杂食性（杂食动物）的观点是无稽之谈；自然界中不存在这样的形式。营养功能的破坏，即外营养（外部营养）的生物学反应，是七种代谢性大流行（文明病）的病因和发病机制基础。1. 动脉粥样硬化和动脉粥样瘤形成；2. 代谢性动脉高血压；3. 代谢综合征；4. 肥胖；5. 胰岛素抵抗综合征；6. 非酒精性脂肪性肝病；7. 内源性高尿酸血症。在营养的生物学功能以及外营养和内营养的生物学反应中对代谢性大流行进行一级预防，将使我们能够理解预防行动的理论基础和实施方法，这些预防行动将决定未来营养的特征。
