Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 10002, Taiwan, ROC.
Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology, Universita Politecnica delle Marche, Ancona, Italy.
Behav Brain Res. 2019 May 17;364:149-156. doi: 10.1016/j.bbr.2019.02.020. Epub 2019 Feb 12.
Several neurodegenerative disorders, namely Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease, share common pathophysiological features, such as (1) cognitive deficits, (2) glutamatergic hyperactivity-related excitotoxicity, and (3) deposition of α-synuclein (α-syn) and β-amyloid (Aβ). Ceftriaxone (CEF) is a well-tested and safe drug that has been used as an antibiotic for several decades. Recent studies have demonstrated the following effects of CEF: (1) increasing glutamate transporter-1 expression and glutamate reuptake and suppressing excitotoxicity, (2) binding well with α-syn and inhibition of α-syn polymerization, (3) modulating expression of genes related to Aβ metabolism, and (4) enhancing neurogenesis and recovery of neuronal density. In addition, our data revealed that CEF ameliorates seizure and abnormal neuronal firing in the brain. These results suggest the potential of CEF in treating neuronal disorders. This paper addresses the effects and pharmacology of CEF.
几种神经退行性疾病，如帕金森病痴呆、路易体痴呆和阿尔茨海默病，具有共同的病理生理特征，如（1）认知缺陷，（2）谷氨酸能过度活跃相关的兴奋性毒性，和（3）α-突触核蛋白（α-syn）和β-淀粉样蛋白（Aβ）的沉积。头孢曲松（CEF）是一种经过充分测试和安全的药物，已被用作抗生素数十年。最近的研究表明 CEF 具有以下作用：（1）增加谷氨酸转运体-1 的表达和谷氨酸再摄取，抑制兴奋性毒性，（2）与 α-syn 结合良好并抑制 α-syn 聚合，（3）调节与 Aβ代谢相关的基因表达，和（4）增强神经发生和神经元密度的恢复。此外，我们的数据显示 CEF 可改善大脑中的癫痫发作和异常神经元放电。这些结果表明 CEF 在治疗神经元疾病方面具有潜力。本文探讨了 CEF 的作用和药理学。
