Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Nephrology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
Life Sci. 2019 Mar 15;221:348-353. doi: 10.1016/j.lfs.2019.02.023. Epub 2019 Feb 12.
Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. CAD has been widely used as an antioxidant and a vascular protective agent. At present, the application of Calcium Dobesilate is mainly related to Micro-vascular damage-related diseases, such as diabetic retinopathy (DR) and diabetic nephropathy (DN), and it is found to significantly improve the related symptoms. Its beneficial effects make it an attractive therapeutic compound especially in the early stages of these diseases. Scholars at home and abroad have studied the effectiveness, safety, and mechanisms of the related diseases, furthermore, the subjects involved patients and animal models, they have found some new clinical effects of this medicine. This paper makes a brief summary of a research progress of clinical application about Vascular injury related diseases and other aspects.
微血管疾病及其相关并发症仍然是全球范围内的一个重大健康问题。微血管受累导致的血管病变导致血流受损，并导致一个或多个靶器官（即心脏、肾脏、眼睛和神经系统）的损伤和功能障碍。羟苯磺酸钙药物（CAD）是一种已确立的血管活性和血管保护药物，在几项实验研究和不同的糖尿病微血管并发症动物模型中显示出独特的、多靶点作用模式。CAD 已被广泛用作抗氧化剂和血管保护剂。目前，羟苯磺酸钙的应用主要与微血管损伤相关疾病有关，如糖尿病视网膜病变（DR）和糖尿病肾病（DN），并发现它能显著改善相关症状。其有益的作用使其成为一种有吸引力的治疗化合物，特别是在这些疾病的早期阶段。国内外学者对相关疾病的有效性、安全性和机制进行了研究，涉及患者和动物模型等方面，发现了该药的一些新的临床疗效。本文对血管损伤相关疾病及其他方面的临床应用研究进展作一简要综述。
