Health Services Vocational School, Igdır University, 76000 Igdır, Turkey.
Department of Science, Faculty of Education, Muş Alparslan University, 49250 Muş, Turkey.
Bioorg Chem. 2019 May;86:420-427. doi: 10.1016/j.bioorg.2019.02.013. Epub 2019 Feb 5.
A series of substituted pyrazole compounds (1-8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1-8 and 9a, b) were emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes with K values in the range of 1.03 ± 0.23-22.65 ± 5.36 µM for hCA I, 1.82 ± 0.30-27.94 ± 4.74 µM for hCA II, and 48.94 ± 9.63-116.05 ± 14.95 µM for AChE, respectively. Docking studies were performed for the most active compounds, 2 and 5, and binding mode between the compounds and the receptors were determined.
合成了一系列取代的吡唑化合物（1-8 和 9a、b），并通过红外光谱、核磁共振和质谱分析对其结构进行了表征。这些得到的新型吡唑衍生物（1-8 和 9a、b）对胞质碳酸酐酶 I 和 II 同工酶（hCA I 和 II）和乙酰胆碱酯酶（AChE）表现出有效的抑制作用，其 K 值范围为 1.03±0.23-22.65±5.36µM（hCA I）、1.82±0.30-27.94±4.74µM（hCA II）和 48.94±9.63-116.05±14.95µM（AChE）。对最活跃的化合物 2 和 5 进行了对接研究，确定了化合物与受体之间的结合模式。
