Institute of Plant Protection and Agro-Product Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, China.
Key Laboratory of Agro-Product Safety Risk Evaluation (Hefei), Ministry of Agriculture, Hefei 230031, China.
Molecules. 2019 Feb 15;24(4):692. doi: 10.3390/molecules24040692.
Kresoxim-methyl is a high-efficiency and broad-spectrum fungicide used for the control of rice fungal diseases; however, its residues after application potentially threaten human health. Investigations on the dissipation of kresoxim-methyl residue in rice field systems and dietary risk assessment of kresoxim-methyl in humans are limited. The present study employed the QuEChERS-GC-MS/MS method for residue analysis of kresoxim-methyl in rice plants, brown rice, and rice husks. The samples were extracted with acetonitrile and purified by PSA, C column, and GCB. The average recovery of the spiked target compounds in the three matrices was between 80.5% and 99.3%, and the RSD was between 2.1% and 7.1%. The accuracy and precision of the method is in accordance with the requirements of residue analysis methods. Dissipation dynamic testing of kresoxim-methyl in rice plants indicated a half-life within the range of 1.8⁻6.0 days, and a rapid dissipation rate was detected. Dietary intake risk assessment showed that the national estimated daily intake () of kresoxim-methyl in various Chinese subpopulations was 0.022⁻0.054 μg/(kg bw·days), and the risk quotient () was 0.0000055⁻0.00014%. These findings indicate that the risk for chronic dietary intake of kresoxim-methyl in brown rice is relatively low. The present study provides information and theoretical basis for guiding the scientific use of kresoxim-methyl in rice fields and evaluating its dietary risk in brown rice.
甲霜灵 - 锰锌是一种高效广谱杀菌剂，用于防治水稻真菌病害；然而，其在应用后的残留可能会威胁人类健康。目前，关于甲霜灵在稻田系统中的残留消解以及人类摄入甲霜灵的膳食风险评估的研究还很有限。本研究采用 QuEChERS-GC-MS/MS 方法对水稻植株、糙米和稻壳中的甲霜灵残留进行分析。样品用乙腈提取，经 PSA、C 柱和 GCB 净化。在三种基质中，目标化合物的平均加标回收率在 80.5%至 99.3%之间，RSD 在 2.1%至 7.1%之间。该方法的准确度和精密度符合残留分析方法的要求。甲霜灵在水稻植株中的消解动态测试表明，其半衰期在 1.8⁻6.0 天之间，消解速度较快。膳食摄入风险评估显示，中国不同亚群人群对甲霜灵的国家估计日摄入量（）为 0.022⁻0.054 μg/（kg bw·days），风险商数（）为 0.0000055⁻0.00014%。这些结果表明，糙米中慢性膳食摄入甲霜灵的风险相对较低。本研究为指导甲霜灵在稻田中的科学使用以及评估其在糙米中的膳食风险提供了信息和理论依据。
