Department of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.
J Chem Phys. 2019 Feb 14;150(6):064904. doi: 10.1063/1.5080177.
We investigate the phase separation of a ternary lipid bilayer including n-alkane and construct the ternary phase diagram. When a certain proportion of a long n-alkane is mixed with a binary mixture of lipids, which exhibit the disordered liquid-crystalline phase and the ordered gel phase at room temperature, we observed the characteristic morphology of bilayers with phase separation. The ordered bilayer forms flat and rigid domains, which is connected or rimmed with flexible domains in the disordered phase. The asymmetric emergence of the phase separation region close to the ordered phase side is interpreted based on the almost equal distribution of the n-alkane to the ordered and disordered phase domains.
我们研究了包含长链烷烃的三元脂质双层的相分离，并构建了三元相图。当一定比例的长链烷烃与在室温下表现为无序液晶相和有序凝胶相的双脂质混合物混合时，我们观察到具有相分离的双层膜的特征形态。有序双层形成平坦且刚性的域，其与无序相中柔性的域相连或围绕。相分离区域接近有序相侧的不对称出现可以根据长链烷烃在有序相和无序相域中的几乎相等分布来解释。
