Brigham and Women's Hospital, Department of Gynecologic Oncology, Boston, Massachusetts; Massachusetts General Hospital, Department of Gynecologic Oncology, Boston, Massachusetts.
Brigham and Women's Hospital, Department of Gynecologic Oncology, Boston, Massachusetts.
Curr Probl Cancer. 2019 Oct;43(5):443-449. doi: 10.1016/j.currproblcancer.2019.01.006. Epub 2019 Feb 7.
An 83-year-old woman presented with postmenopausal bleeding ultimately leading to surgery and a final diagnosis of stage IB grade 3 endometrioid endometrial adenocarcinoma. The tumor board reviewed current literature regarding the efficacy of sentinel lymph node dissection in appropriately allocating stage in high-grade endometrial cancer. The optimal role of adjuvant treatment in this setting is unclear. Current literature surrounding adjuvant radiation and chemotherapy, as well as current practices in molecular diagnostics for endometrial cancer were reviewed. The tumor board concluded that literature surrounding sentinel lymph node evaluation in high-grade endometrial cancers is robust enough to incorporate into clinical practice. Based on the best available evidence, a decision was made to treat with external beam radiotherapy and withhold chemotherapy.
一位 83 岁的女性因绝经后出血就诊，最终接受了手术，确诊为 I 期 B 级 3 级子宫内膜样腺癌。肿瘤委员会审查了目前关于前哨淋巴结清扫术在适当分期中的有效性的文献，这些文献涉及高级别子宫内膜癌。在这种情况下，辅助治疗的最佳作用尚不清楚。目前对子宫内膜癌辅助放疗和化疗的文献，以及目前在分子诊断方面的实践进行了回顾。肿瘤委员会得出结论，目前关于高级别子宫内膜癌前哨淋巴结评估的文献足够充分，可以纳入临床实践。基于最佳可用证据，决定采用外照射放疗，不进行化疗。
